微晶纤维素的含量测定-第三军医大学学报.doc

微晶纤维素的含量测定 刘春霞 李国成1* 黄际薇2（1.中山大学附属第二医院药学部 广州 510120，2. 中山大学附属第三医院药剂科，广州市，510630） 摘要 目的：探讨微晶纤维素的含量测定方法。方法：自拟方法：以工作基准试剂草酸钠标定硫酸铈滴定液，以硫酸铈滴定液标定硫酸亚铁铵滴定液，再用硫酸亚铁铵滴定液对微晶纤维素中纤维素含量测定方法进行研究；药典方法：依据《中国药典》2005年版以三氧化二砷标定硫酸铈滴定液，以硫酸铈滴定液标定硫酸亚铁铵滴定液，再用硫酸亚铁铵滴定液对微晶纤维素中纤维素含量测定方法。结果：自拟方法与对药典方法对微晶纤维素中纤维素含量测定方法进行研究相比较，其RSD 0.05%。结论：以工作基准试剂草酸钠标定硫酸铈滴定液，以硫酸铈滴定液标定硫酸亚铁铵滴定液，再用硫酸亚铁铵滴定液对微晶纤维素中纤维素含量测定方法进行研究，方法可靠，其微晶纤维素的含量测定方法值得推广。 关键词：微晶纤维素 含量测定 DETERMINATION OF MICROCRYSTALLINE CELLULOSE Liu Chun-xia1 Li Guo-cheng1* Huang Ji-wei2 (1. Department of Pharmacy, the Second Affiliated Hospital, Sun Yat -set university, Guangzhou ,510120. 2. Department of Pharmacy, the Third Affiliated Hospital, Sun Yat -set university,.Guangzhou , 510630) ABSTRACT OBJECTIVE : Discussion of microcrystalline cellulose determination. METHODS : Since the proposed method: in order to benchmark the work of sodium oxalate reagent cerium sulfate titration calibration fluid. Cerium sulfate titration with ferrous ammonium sulfate solution titration calibration fluid. Ferrous ammonium sulfate and then titrated on microcrystalline cellulose determination in cellulose research. Pharmacopoeia method: According to Chinese Pharmacopoeia in 2005 of arsenic trioxide calibration liquid cerium sulfate titration. Cerium sulfate titration with ferrous ammonium sulfate solution titration calibration fluid. Ferrous ammonium sulfate and then titrated on microcrystalline cellulose in the cellulose determination.RESULTS: Since the proposed method with the USP method of microcrystalline cellulose in the cellulose determination to study, compared to the RSD 0.05%..CONCLUSION: To the work of demarcation of the baseline sodium oxalate reagent cerium sulfate titration liquid to liquid cerium sulfate titration Titration Calibration ferrous ammonium sulfate solution, and then ammonium ferrous sulfate titration on microcrystalline cellulose in the cellulose content determination methods of research, reliable method , the microcrystalline cel