Lamin A Rod Domain Mutants Target Heterochromatin Protein 1α and β for Proteasomal Degradation by Activation of F-Box Protein, FBXW10 英文参考文献.docVIP

LaminARodDomainMutantsTargetHeterochromatin Protein1aandbforProteasomalDegradationby ActivationofF-BoxProtein,FBXW10 PankajChaturvedi,VeenaK.Parnaik* CentreforCellularandMolecularBiology(CSIR),Hyderabad,India Abstract Background: Lamins are major structural proteins of the nucleus and contribute to the organization of various nuclear functions.MutationsinthehumanlaminAgenecauseanumberofhighlydegenerativediseases,collectivelytermedas laminopathies. Cells expressing lamin mutations exhibit abnormal nuclear morphology and altered heterochromatin organization;however,themechanismsresponsiblefort