Large-Scale Discovery of Promoter Motifs in Drosophila melanogaster 英文参考文献.docVIP

Large-ScaleDiscoveryofPromoterMotifsin Drosophilamelanogaster Thomas A.Down1*,Casey M. Bergman2,Jing Su1,Tim J.P.Hubbard1 1WellcomeTrustSangerInstitute,Hinxton,Cambridge,UnitedKingdom,2FacultyofLifeSciences,UniversityofManchester,Manchester,UnitedKingdom Akeystepinunderstandinggeneregulationistoidentifytherepertoireoftranscriptionfactorbindingmotifs(TFBMs) that form the building blocks of promoters and other regulatory elements. Identifying these experimentally is very laborious,andthenumberofTFBMsdiscoveredremainsrelativelysmall,especiallywhencomparedwiththehundreds of transcription factor