Mapping Traumatic Axonal Injury Using Diffusion Tensor Imaging Correlations with Functional Outcome 英文参考文献.docVIP

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Mapping Traumatic Axonal Injury Using Diffusion Tensor Imaging Correlations with Functional Outcome 英文参考文献.doc

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Mapping Traumatic Axonal Injury Using Diffusion Tensor Imaging Correlations with Functional Outcome 英文参考文献

MappingTraumaticAxonalInjuryUsingDiffusionTensor Imaging:CorrelationswithFunctionalOutcome VirginiaNewcombe1,2*,DorisChatfield1,2,JoanneOuttrim1,2,SarahVowler3,AnneManktelow1,2 ,Justin Cross4,DanielScoffings4,MartinColeman2,PeterHutchinson2,5,JonathanColes1,2,T.Adrian Carpenter2,JohnPickard2,5,GuyWilliams2,DavidMenon1,2 1University Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom, 2Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, UniversityofCambridge,Cambridge,UnitedKingdom,3CentreforAppliedMedicalStatistics,DepartmentofPublicHealthandPrimaryCare,UniversityofCambridge, Cambridge,UnitedKingdom,4DepartmentofRadiology,UniversityofCambridge,Addenbrooke’sHospital,Cambridge,UnitedKingdom,5AcademicNeurosurgeryUnit, DepartmentofClinicalNeurosciences,UniversityofCambridge,Cambridge,UnitedKingdom Abstract Background:Traumaticbraininjuryisamajorcauseofmorbidityandmortalityworldwide.Amelioratingtheneurocognitive and physical deficits that accompany traumatic brain injury would be of substantial benefit, but the mechanisms that underliethemarepoorlycharacterized.Thisstudyaimedtousediffusiontensorimagingtorelateclinicaloutcometothe burdenofwhitematterinjury. Methodology/PrincipalFindings:Sixty-eightpatients,categorizedbytheGlasgowOutcomeScore,underwentmagnetic resonanceimagingatamedianof11.8months(range6.6monthsto3.7years)yearspostinjury.Controldatawereobtained from36age-matchedhealthyvolunteers.Meanfractionalanisotropy,apparentdiffusioncoefficient(ADC),andeigenvalues were obtained for regions of interest commonly affected in traumatic brain injury. In a subset of patients where conventional magnetic resonance imaging was completely normal, diffusion tensor imaging was able to detect clear abnormalities.SignificanttrendsofincreasingADCwithworseoutcomewerenotedinallregionsofinterest.Inthewhite matterregionsofinterestworseclinicaloutcomecorrespondedwithsignificanttrendsofdecreasingfractionalanisotropy. Conclusions/Significance: This