Meta-Analysis of Cytochrome P-450 2C9 Polymorphism and Colorectal Cancer Risk 英文参考文献.docVIP

Meta-AnalysisofCytochromeP-4502C9Polymorphism andColorectalCancerRisk ShuoLiang1.,JingsongHu2.,WeijunCao1*,SanjunCai2* 1DepartmentofRespiratory,PulmonaryHospitalofShanghai,TongjiUniversitySchoolofMedicine,Shanghai,People’sRepublicofChina,2DepartmentofColorectal Cancer,ShanghaiCancerCenter,FudanUniversitySchoolofMedicine,Shanghai,People’sRepublicofChina Abstract Background: CYP2C9 encodes a member of the cytochrome P450 superfamily of enzymes which play a central role in activatinganddetoxifyingmanycarcinogensandendogenouscompoundsthoughttobeinvolvedinthedevelopmentof colorectalcancer(CRC).Inthepastdecade,therelationshipbetweenCYP2C9commonpolymorphisms(R144CandI359L) and CRC has been reported in various ethnic groups; however, these studies have yielded contradictory results. To investigatethisinconsistency,weperformedthismeta-analysis. Methods:DatabasesincludingPubmed,EMBASE,WebofScienceandChinaNationalKnowledgeInfrastructure(CNKI)were searchedtofindrelevantstudies.Oddsratios(ORs)with95%confidenceintervals(CIs)wereusedtoassessthestrengthof association. Results:Atotalof13articlesinvolving9,463casesand11,416controlswereincluded.Overall,thesummaryoddsratioof CRC was 0.98 (95% CI: 0.8921.06) and 0.99 (95% CI: 0.8721.14) for CYP2C9 144C and 359L alleles, respectively. No significant results were observed using dominant or recessive genetic model for these polymorphisms. In the stratified analysesaccordingtoethnicityandsex,noevidenceofanygene-diseaseassociationwasobtained. Conclusions:Thismeta-analysissuggeststhattheCYP2C9maynotbeassociatedwithcolorectalcancerdevelopment. Citation: Liang S, Hu J, Cao W, Cai S (2012) Meta-Analysis of Cytochrome P-450 2C9 Polymorphism and Colorectal Cancer Risk. PLoS ONE 7(11): e49134. doi:10.1371/journal.pone.0049134 Editor:PalBelaSzecsi,GentofteUniversityHospital,Denmark ReceivedJuly2,2012;AcceptedOctober4,2012;PublishedNovember7,2012 Copyright: ? 2012 Liang etal. This is an open-access article distributed under the terms of the Creativ