MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2-heptylquinoline) 英文参考文献.docVIP

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MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2-heptylquinoline) 英文参考文献.doc

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MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2-heptylquinoline) 英文参考文献

MexEF-OprNEffluxPumpExportsthePseudomonas QuinoloneSignal(PQS)PrecursorHHQ(4-hydroxy-2- heptylquinoline) MartinG.Lamarche,EricDe′ziel* INRS-InstitutArmand-Frappier,Laval,Que′bec,Canada Abstract Bacterialcellshaveevolvedthecapacitytocommunicatebetweeneachotherviasmalldiffusiblechemicalsignalstermed autoinducers. Pseudomonas aeruginosa is an opportunistic pathogen involved, among others, in cystic fibrosis complications. Virulence of P. aeruginosa relies on its ability to produce anumber of autoinducers, including 4-hydroxy- 2-alkylquinolines(HAQ).Inacelldensity-dependentmanner,accumulatedsignalsinducetheexpressionofmultipletargets, especially virulence factors. This phenomenon, called quorum sensing, promotes bacterial capacity to cause disease. Furthermore,P.aeruginosapossessesmanymultidrugeffluxpumpsconferringadaptiveresistancetoantibiotics.Activityof someoftheseeffluxpumpsalsoinfluencesquorumsensing.ThepresentstudydemonstratesthattheMexEF-OprNefflux pump modulates quorum sensing through secretion of a signalling molecule belonging to the HAQ family. Moreover, activationofMexEF-OprNreducesvirulencefactorexpressionandswarmingmotility.SinceMexEF-OprNcanbeactivatedin infectedhostsevenintheabsenceofantibioticselectivepressure,itcouldpromoteestablishmentofchronicinfectionsin thelungsofpeoplesufferingfromcysticfibrosis,thusdiminishingtheimmuneresponsetovirulencefactors.Therapeutic drugs that affect multidrug efflux pumps and HAQ-mediated quorum sensing would be valuable tools to shut down bacterialvirulence. Citation: Lamarche MG, E (2011) MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2- De′ziel heptylquinoline).PLoSONE6(9):e24310.doi:10.1371/journal.pone.0024310 Editor:MichaelOtto,NationalInstitutesofHealth,UnitedStatesofAmerica ReceivedApril11,2011;AcceptedAugust8,2011;PublishedSeptember21,2011 Copyright:?2011Lamarche,De′ziel.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLice