MicroRNA-550a Acts as a Pro-Metastatic Gene and Directly Targets Cytoplasmic Polyadenylation Element-Binding Protein 4 in Hepatocellular Carcinoma 英文参考文献.docVIP

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MicroRNA-550a Acts as a Pro-Metastatic Gene and Directly Targets Cytoplasmic Polyadenylation Element-Binding Protein 4 in Hepatocellular Carcinoma 英文参考文献.doc

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MicroRNA-550a Acts as a Pro-Metastatic Gene and Directly Targets Cytoplasmic Polyadenylation Element-Binding Protein 4 in Hepatocellular Carcinoma 英文参考文献

MicroRNA-550aActsasaPro-MetastaticGeneand DirectlyTargetsCytoplasmicPolyadenylationElement- BindingProtein4inHepatocellularCarcinoma QiTian1,LinhuiLiang1,JieDing1,RuopengZha1,HaibingShi1,QifengWang1,ShenglinHuang1, WeijieGuo1,ChaoGe1,TaoyangChen2,JinjunLi1,XianghuoHe1* 1StateKeyLaboratoryofOncogenesandRelatedGenes,ShanghaiCancerInstitute,RenjiHospital,ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai,China, 2QiDongLiverCancerInstitute,QiDong,Jiangsu,China Abstract MicroRNAs(miRNAs)areaclassofsmall,non-codingRNAmoleculesthatareoftenfoundatchromosomalbreakpointsand playavitalroleinhumancancer.OurpreviousstudyfoundthatmiR-550a,afrequentlyamplifiedmiRNAon7p14.3,was upregulatedinhepatocellularcarcinoma(HCC).However,thepossiblefunctionsandmolecularmechanismsofmiR-550ain HCCremainunknown.Inthisstudy,gain-of-functionandloss-of-functionassaysrevealedthatmiR-550amarkedlypromoted HCCcellmigrationandinvasion.Inaddition,wediscoveredthatcytoplasmicpolyadenylationelementbindingprotein4 (CPEB4) was a potential target of miR-550a in HCC. Further analyses showed that knockdown of CPEB4 expression significantlyfacilitatedHCCcellmigrationandinvasion,whichphenocopiedtheeffectsofmiR-550aonHCCcells.Moreover, adecreaseinCPEB4expressionmediatedmiR-550a-inducedlivercancercellmigrationandinvasion.Interestingly,CPEB4is frequentlydownregulatedinHCC,anditsexpressionlevelscorrelate withtheoverallsurvivalofHCCpatients. Together, theseresultssuggestedthatthisnewlyidentifiedmiR-550a-CPEB4axismaybeinvolvedinHCCcellmetastasis.Moreover, theexpressionlevelsofCPEB4couldbeusedtopredictoutcomesinHCCpatients.Ourfindingsprovidenovelpotential targetsforHCCtherapyandprognosis. Citation: Tian Q, Liang L, Ding J, Zha R, Shi H, et al. (2012) MicroRNA-550a Acts as a Pro-Metastatic Gene and Directly Targets Cytoplasmic Polyadenylation Element-BindingProtein4inHepatocellularCarcinoma.PLoSONE7(11):e48958.doi:10.1371/journal.pone.0048958 Editor:Xin-YuanGuan,TheUniversityofHongKong,China ReceivedAugust14,20