Modulation of Immunoglobulin Production by Invariant Vα19-Jα33 TCR-Bearing Cells 英文参考文献.docVIP

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Modulation of Immunoglobulin Production by Invariant Vα19-Jα33 TCR-Bearing Cells 英文参考文献.doc

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Modulation of Immunoglobulin Production by Invariant Vα19-Jα33 TCR-Bearing Cells 英文参考文献

ModulationofImmunoglobulinProductionbyInvariant Va19-Ja33TCR-BearingCells MichioShimamura1,2,3*,Yi-YingHuang2,HiroshiHidaka2 1Tsukuba Research Center for Interdisciplinary Materials Science and Graduate School of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan, 2DevelopmentalImmunologyUnit,MitsubishiKagakuInstituteofLifeSciences,Machida,Tokyo,Japan,3FoundationforAdvancementofInternationalScience,Tsukuba, Ibaraki,Japan Abstract WehavepreviouslyshownthatinvariantVa19-Ja33TCR+(Va19iT)cellssuppressthediseaseprogressinsomemodelsfor organ specific autoimmune diseases and type IV allergy that deteriorate along with decline to excess in Th1- or Th17- immunity.Inthisstudy,weexaminedtheeffectsofover-generationofVa19iTcellsontheTh2-controlledimmunoglobulin isotypeproductioninthemodelsfortypeIallergy.IgEproductionbyinvariantVa19-Ja33TCRtransgenic(Tg)micewas suppressedcomparedwiththatbynon-Tgcontrolsfollowingadministrationwithgoatanti-mouseIgDantiserumorOVA, whileIgG2aproductionwasnotinfluencedbytheintroductionofthetransgeneintotherecipients.IgEproductionbywild + typemicewassimilarlyreducedwhentheyweresubjectedtoadoptivetransferwithinvariantVa19-Ja33TCRTg butnot Tg2cellspriortoimmunization.Furthermore,thesuppressionofIgEproductionbytheserecipientswasenhancedwhen theywerepreviouslyadministeredwithaVa19iTcellactivator,oneofthemodifieda-mannosylceramides.Insummary,itis suggestedthatVa19iTcellshavepotentialtoparticipateinthehomeostasisofimmunityandthattheysuppressdisease progressionresultingfromnotonlyTh1-butalsoTh2-immunityexcess. Citation: Shimamura M, Huang Y-Y, Hidaka H (2011) Modulation of Immunoglobulin Production by Invariant Va19-Ja33 TCR-Bearing Cells. PLoS ONE 6(6): e20915.doi:10.1371/journal.pone.0020915 Editor:JoseAlberola-Ila,OklahomaMedicalResearchFoundation,UnitedStatesofAmerica ReceivedFebruary3,2011;AcceptedMay12,2011;PublishedJune16,2011 Copyright:?2011Shimamuraetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCom