Mortality Rates Across 25-Hydroxyvitamin D (25[OH]D) Levels among Adults with and without Estimated Glomerular Filtration Rate 60 mlmin1.73 m2 The Third National Health and Nutrition Examination Survey 英文参考文献.docVIP

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Mortality Rates Across 25-Hydroxyvitamin D (25[OH]D) Levels among Adults with and without Estimated Glomerular Filtration Rate 60 mlmin1.73 m2 The Third National Health and Nutrition Examination Survey 英文参考文献.doc

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Mortality Rates Across 25-Hydroxyvitamin D (25[OH]D) Levels among Adults with and without Estimated Glomerular Filtration Rate 60 mlmin1.73 m2 The Third National Health and Nutrition Examination Survey 英文参考文献

MortalityRatesAcross25-HydroxyvitaminD(25[OH]D) LevelsamongAdultswithandwithoutEstimated GlomerularFiltrationRate,60ml/min/1.73m2 :The ThirdNationalHealthandNutritionExaminationSurvey HollyKramer1,2,3*,ChrisSempos4,GuichanCao1,AmyLuke1,DavidShoham1,RichardCooper1, RamonDurazo-Arvizu1 1DepartmentofPreventiveMedicineandEpidemiology,LoyolaUniversityMedicalCenter,Maywood,Illinois,UnitedStatesofAmerica,2DepartmentofMedicine,Loyola UniversityMedicalCenter,Maywood,Illinois,UnitedStatesofAmerica,3DivisionofNephrologyandHypertension,LoyolaUniversityMedicalCenter,Maywood,Illinois, UnitedStatesofAmerica,4OfficeofDietarySupplements,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesofAmerica Abstract Background:Previousstudiesexploringtheassociationbetween25[OH]Dlevelsandmortalityinadultswithandwithout kidneydiseaseutilized25[OH]DthresholdsthathaverecentlybeenscrutinizedbytheInstituteofMedicineCommitteeto ReviewDietaryReferencesIntakesforVitaminDandCalcium. Objective: We explored all-cause mortality rates across the spectrum of 25[OH]D levels over an eighteen-year follow-up amongadultswithandwithoutanestimatedglomerularfiltrationrate(eGFR),60ml/min/1.73m2. Design:Thestudyincluded1,097U.S.adultswitheGFR,60ml/min/1.73m2and14,002adultswitheGFR$60ml/min/ 1.73m2.Mortalityratesandrateratios(RR)across25[OH]DgroupswerecalculatedwithPoissonregressionandrestricted cubicsplineswhileadjustingforcovariates. Results: Prevalence of 25[OH]D levels ,30 and ,20ng/ml among adults with eGFR ,60ml/min/1.73m2 was 76.5% (population estimate 6.2 million) and 35.4% (population estimate 2.9 million), respectively. Among adults with eGFR $60ml/min/1.73m2,70.5%had25[OH]Dlevels,30ng/ml(populationestimate132.2million)while30.3%had25[OH]D levels,20ng/ml(populationestimate56.8million).Significantlyhighermortalityrateswerenotedamongindividualswith 25[OH]Dlevels,12ng/mlcomparedtoreferentgroup(24to,30ng/ml):RR1.41(95%CI1.17,1.71)amongindividuals witheGFR,60ml/min/1.73m2 andRR1.32(95%CI1.13,1.56) among