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MRI Findings in 77 Children with Non-Syndromic Autistic Disorder 英文参考文献
MRIFindingsin77ChildrenwithNon-SyndromicAutistic
Disorder
NathalieBoddaert1,2*,Mo?nicaZilbovicius1,2,AnnePhilipe4,LaurenceRobel5,MarieBourgeois6,
CatherineBarthe′lemy7,DavidSeidenwurm2,IsabelleMeresse1,8,LaurenceLaurier1,IsabelleDesguerre6,
NadiaBahi-Buisson6,FrancisBrunelle1,2,ArnoldMunnich4,YvesSamson8,Marie-ChristineMouren3,
NadiaChabane3
1INSERM-CEAU797,ServiceHospitalierFre′de′ric Joliot,CEA,Orsay,France,2ServicedeRadiologiePe′diatrique,U797,Ho?pitalNeckerEnfantsMalades,AP-HP,ParisV,
Paris,France,3ServicedePe′dopsychiatrie, Ho?pitalRobertDebre′, AP-HP,Paris,France,4GeneticClinicandResearchUnitINSERM781,Ho?pitalNecker-EnfantsMalades
andUniversite′ParisVRene′Descartes,Paris,France,5ServicedePe′dopsychiatrie,Ho?pitalNeckerEnfantsMalades,AP-HP,ParisV,Paris,France,6ServicedeNeurologieet
Me′tabolisme,Ho?pitalNeckerEnfantsMalades,AP-HP,ParisV,Paris,France,7INSERMU916,CHUBretonneau,Tours,France,8ServicedesUrgencesCerebro-Vasculaires,
GroupeHospitalierPitie′-Salpe?trie`re,AP-HP,Paris,France
Abstract
Background:TheclinicalrelevanceofMRscanninginchildrenwithautismisstillanopenquestionandmustbeconsidered
inlightoftheevolutionofthistechnology.MRIwasjudgedtobeofinsufficientvaluetobeincludedinthestandardclinical
evaluationofautismaccordingtotheguidelinesoftheAmericanAcademyofNeurologyandChildNeurologySocietyin
2000 [1].However, thisstatement wasbasedon resultsobtained fromsmallsamples ofpatients and,moreimportantly,
includedmostlyinsufficientMRIsequences.Ourmainobjectivewastoevaluatetheprevalenceofbrainabnormalitiesina
largegroupofchildrenwithanon-syndromicautisticdisorder(AD)usingT1,T2andFLAIRMRIsequences.
Methodology:MRIinspectionof77childrenandadolescentswithnon-syndromicAD(meanage7.463.6)wasperformed.
AllmettheDSM-IVandADI–Rcriteriaforautism.Basedonrecommendedclinicalandbiologicalscreenings,weexcluded
patients with infectious, metabolic or genetic diseases, seizures or any other neurological symptoms. Identical MRI
inspectionsof77children(meanage7.064.2)withoutA
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