Multi-Method Analysis of MRI Images in Early Diagnostics of Alzheimers Disease 英文参考文献.docVIP
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Multi-Method Analysis of MRI Images in Early Diagnostics of Alzheimers Disease 英文参考文献
Multi-MethodAnalysisofMRIImagesinEarly
DiagnosticsofAlzheimer’sDisease
RobinWolz1.,ValtteriJulkunen2.,JuhaKoikkalainen3,EiniNiskanen2,4,DongPingZhang1 ,Daniel
Rueckert1,HilkkaSoininen2,5,JyrkiLo¨tjo¨nen3*,theAlzheimer’sDiseaseNeuroimagingInitiative
1Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom, 2Department of Neurology, Kuopio University
Hospital,Kuopio,Finland,3KnowledgeIntensiveServices,VTTTechnicalResearchCentreofFinland,Tampere,Finland,4DepartmentofAppliedPhysics,Universityof
EasternFinland,Kuopio,Finland,5InstituteofClinicalMedicine,Neurology,UniversityofEasternFinland,Kuopio,Finland
Abstract
The role of structural brain magnetic resonance imaging (MRI) is becoming more and more emphasized in the early
diagnosticsofAlzheimer’sdisease(AD).Thisstudyaimedtoassesstheimprovementinclassificationaccuracythatcanbe
achieved by combining features from different structural MRI analysis techniques. Automatically estimated MR features
used are hippocampal volume, tensor-based morphometry, cortical thickness and a novel technique based on manifold
learning.BaselineMRIsacquiredfromall834subjects(231healthycontrols(HC),238stablemildcognitiveimpairment(S-
MCI),167MCItoADprogressors(P-MCI),198AD)fromtheAlzheimer’sDiseaseNeuroimagingInitiative(ADNI)database
were used for evaluation. We compared the classification accuracy achieved with linear discriminant analysis (LDA) and
supportvectormachines(SVM).Thebestresultsachievedwithindividualfeaturesare90%sensitivityand84%specificity
(HC/AD classification), 64%/66% (S-MCI/P-MCI) and 82%/76% (HC/P-MCI) with the LDA classifier. The combination of all
featuresimprovedtheseresultsto93%sensitivityand85%specificity(HC/AD),67%/69%(S-MCI/P-MCI)and86%/82%(HC/
P-MCI).ComparedwithpreviouslypublishedresultsintheADNIdatabaseusingindividualMR-basedfeatures,thepresented
resultsshowthatacomprehensiveanalysisofMRIimagescombiningmultiplefeaturesimprovesclassificationaccuracyand
predictive po
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