Myeloid IκBα Deficiency Promotes Atherogenesis by Enhancing Leukocyte Recruitment to the Plaques 英文参考文献.docVIP
- 1、本文档共8页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Myeloid IκBα Deficiency Promotes Atherogenesis by Enhancing Leukocyte Recruitment to the Plaques 英文参考文献
MyeloidIkBaDeficiencyPromotesAtherogenesisby
EnhancingLeukocyteRecruitmenttothePlaques
PieterGoossens1,MoniqueN.Vergouwe1,MarionJ.J.Gijbels1,2,DanielleM.J.Curfs1,JohannesH.G.
vanWoezik1,MartenA.Hoeksema1,SofiaXanthoulea1,PieterJ.M.Leenen3,RudolfA.Rupec4,MartenH.
Hofker5,MennoP.J.deWinther1*
1Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands, 2Department of Pathology,
Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands, 3Department of Immunology, Erasmus University Medical Center,
Rotterdam,TheNetherlands,4DepartmentofDermatology,Ludwig-Maximilian-University,Munich,Germany,5DepartmentofPathologyandMedicalBiology,Medical
BiologySection,MolecularGenetics,UniversityMedicalCenterGroningen,UniversityofGroningen,Groningen,TheNetherlands
Abstract
ActivationofthetranscriptionfactorNF-kBappearstobeinvolvedindifferentstagesofatherogenesis.Inthispaperwe
investigatetheroleofNF-kBinhibitorIkBainatherosclerosis.Myeloid-specificdeletionofIkBaresultsinlargerandmore
advanced lesions in LDL-R-deficient mice without affecting the compositional phenotype of the plaques or systemic
inflammatorymarkersintheplasma.WeshowthatIkBa-deletedmacrophagesdisplayenhancedadhesiontoaninvitro
endothelialcelllayer,coincidingwithanincreasedexpressionofthechemokineCCL5.Also,invivowefoundthatIkBadel
micehadmoreleukocytesadheringtotheluminalsideoftheendothelialcelllayersthatcovertheatheroscleroticplaques.
Moreover,weintroduceER-MP58inthispaperasanewimmunohistochemicaltoolforquantifyingnewlyrecruitedmyeloid
cellsintheatheroscleroticlesion.ThisstainingconfirmsthatinIkBadelmicemoreleukocytesareattractedtotheplaques.In
conclusion,weshowthatIkBadeletioninmyeloidcellspromotesatherogenesis,probablythroughaninducedleukocyte
recruitmenttoplaques.
Citation: Goossens P, Vergouwe MN, Gijbels MJJ, Curfs DMJ, van Woezik JHG, et al. (2011) Myeloid IkBa Deficiency Promotes Atherogenesis by Enhanc
您可能关注的文档
- Mutations in a P-Type ATPase Gene Cause Axonal Degeneration 英文参考文献.doc
- Mutations in AKAP5 Disrupt Dendritic Signaling Complexes and Lead to Electrophysiological and Behavioral Phenotypes in Mice 英文参考文献.doc
- Mutations in a Guanylate Cyclase GCY-35GCY-36 Modify Bardet-Biedl Syndrome–Associated Phenotypes in Caenorhabditis elegans 英文参考文献.doc
- Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation 英文参考文献.doc
- Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN 英文参考文献.doc
- Mutations in Escherichia coli aceE and ribB Genes Allow Survival of Strains Defective in the First Step of the Isoprenoid Biosynthesis Pathway 英文参考文献.doc
- Mutations Change the Boolean Logic of Gene Regulation 英文参考文献.doc
- Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS) 英文参考文献.doc
- Mutations in or near the Transmembrane Domain Alter PMEL Amyloid Formation from Functional to Pathogenic 英文参考文献.doc
- Mutations in SLC29A3, Encoding an Equilibrative Nucleoside Transporter ENT3, Cause a Familial Histiocytosis Syndrome (Faisalabad Histiocytosis) and Familial Rosai-Dorfman Disease 英文参考文献.doc
最近下载
- 六年级下册总复习《比和比例》说课稿.pdf
- (2023正式版)JBT 14355-2023 发动机尾焰测温用钨铼热电偶丝 .docx VIP
- 骨架油封结构型式标准用途..docx VIP
- 2024第六届(2024年)“信用电力”知识竞赛活动总试题库资料-上(单选题汇总).pdf
- (完整word版)全新版大学英语综合教程4课文原文及翻译.pdf VIP
- 京能集团招聘笔试题库2023.pdf
- 抗震支架施工方案.doc
- 代买车辆协议书(精选5篇).docx VIP
- USP 1207.1 包装完整性和测试方法选择(中英对照).doc
- 山西梅园许村煤业有限公司120万ta矿井兼并重组整合项目环境影响报告书(公示版)-副本.doc VIP
文档评论(0)