Neuroticism Modifies Psychophysiological Responses to Fearful Films 英文参考文献.docVIP

NeuroticismModifiesPsychophysiologicalResponsesto FearfulFilms EmmanuelleReynaud1,2*,MyriamElKhoury-Malhame1,2,Je′ro?meRossier3,OlivierBlin1,4, Ste′phanieKhalfa1,2 1NationalCenterforScientificResearch(CNRS),TimoneNeuroscienceInstitute(INT,UMR7289),Marseille,France,2DepartmentofNeurosciences,FacultyofLifeand Health Sciences, University of the Mediterranean Aix Marseille 2, Marseille, France, 3Institute of Psychology, University of Lausanne, Lausanne, Switzerland, 4Public AssistanceforMarseilleHospitals(APHM),UnitforClinicalPharmacologyandTherapeuticEvaluation(CIC-UPCET),TimoneHospital,Marseille,France Abstract Background:Neuroticismisapersonalitycomponentfrequentlyfoundinanxiousanddepressivepsychiatricdisorders.The influenceofneuroticismonnegativeemotionscouldbeduetoitsactiononstimulirelatedtofearandsadness,butthis remains debated. Our goal was thus to better understand the impact of neuroticism through verbal and physiological assessmentinresponsetostimuliinducingfearandsadnessascomparedtoanothernegativeemotion(disgust). Methods:Fifteenlowneuroticand18highneuroticsubjectswereassessedonanemotionalattendingtaskbyusingfilm excerptsinducingfear,disgust,andsadness.Werecordedskinconductanceresponse(SCR)andcorrugatormuscleactivity (frowning)asindicesofemotionalexpression. Results:SCRwaslargerinhighneuroticsubjectsthaninlowneuroticsforfearrelativetosadnessanddisgust.Moreover, corrugatoractivityandSCRwerelargerinhighthaninlowneuroticsubjectswhenfearwasinduced. Conclusion:Afterdecadesofevidencethatindividualshigherinneuroticismexperiencemoreintenseemotionalreactions to even minor stressors, our results indicate that they show greater SCR and expressive reactivity specifically to stimuli evoking fear rather than to those inducing sadness or disgust. Fear processing seems mainly under the influence of neuroticism. This modulation of autonomic activity by neurotics in response to threat/fear may explain their increased vulnerabilitytoanxiouspsychopathologiessuchasPTSD(posttrau