NFκB1 and NFκBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population 英文参考文献.docVIP

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NFκB1 and NFκBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population 英文参考文献.doc

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NFκB1 and NFκBIA Polymorphisms Are Associated with Increased Risk for Sporadic Colorectal Cancer in a Southern Chinese Population 英文参考文献

NFkB1andNFkBIAPolymorphismsAreAssociatedwith IncreasedRiskforSporadicColorectalCancerina SouthernChinesePopulation ShunxinSong1,2.,DiankeChen1.,JiachunLu4,JiaweiLiao1,YanxinLuo1,2,ZuliYang1,2,XinhuiFu1, XinjuanFan1,YishengWei3,LeiYang4,LeiWang1,2*,JianpingWang1,2 * 1GastrointestinalInstitute ofSunYat-SenUniversity,TheSixthAffiliated HospitalofSunYat-SenUniversity,Guangzhou,People’sRepublicofChina,2Department of ColorectalSurgery,TheSixthAffiliatedHospitalofSunYat-SenUniversity,Guangzhou,People’sRepublicofChina,3DepartmentofGastrointestinalSurgery,TheSecond Affiliated Hospital of Guangzhou Medical College, Guangzhou, People’s Republic of China, 4The Institute for Chemical Carcinogenesis, The State Key Laboratory of RespiratoryDisease,GuangzhouMedicalCollege,Guangzhou,People’sRepublicofChina Abstract Background:NuclearfactorkB(NFkB)playsakeyroleintheregulationofapoptosis.ThefunctionofNFkBisinhibitedby binding to NFkB inhibitor (IkB), and disruption of the balance of NFkB and IkB is related to the development of many diseases, including tumors. Therefore, we hypothesized that the NFkB1 (-94del/insATTG) and NFkBIA (2758 A.G) polymorphismswereassociatedwithcolorectalcancer(CRC)susceptibility. Methods:Inahospital-basedcase–controlstudyof1001CRCpatientsand1005cancer-freecontrolsfrequencymatchedby age and sex, we genotyped polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)methodandperformedluciferaseassaysandWesternblottinganalysistoidentifywhethergeneticvariantsin NFkBIAalteritsgeneexpressionsandfunctionsandthuscancerrisk. Results: Wefoundthat both NFkB1-94 ins/delATTG andNFkBIA 2758A.G polymorphisms werecorrelated with CRCrisk (OR=1.47; 95%CI=1.14–1.86, and OR=1.38; 95% CI=1.14–1.66, respectively). Furthermore, when evaluated these two polymorphisms together, the combined genotypes with 2 variant (risk) alleles (2758GG and -94ins/ins+del/ins ) were associatedwithanincreasedriskofCRC(OR=1.71;95%CI=1.23–2.38)compar