NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness 英文参考文献.docVIP

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NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness 英文参考文献.doc

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NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness 英文参考文献

NMDAReceptorHypofunctionLeadstoGeneralizedand PersistentAberrantcOscillationsIndependentof HyperlocomotionandtheStateofConsciousness TahirHakami1.,NigelC.Jones1.,ElenaA.Tolmacheva2.,JulienGaudias2¤,JosephChaumont2 ,Michael Salzberg3,TerenceJ.O’Brien1,DidierPinault2* 1DepartmentofMedicine,RoyalMelbourneHospital,UniversityofMelbourne,Parkville,Australia,2INSERMU666,Physiopathologieetpsychopathologiecognitivedela schizophre′nie, Universite′ de Strasbourg, Faculte′ de Me′decine, Strasbourg, France, 3Department of Psychiatry, St Vincent’s Hospital,University of Melbourne,Fitzroy, Victoria,Australia Abstract Background:ThepsychotomimeticsketamineandMK-801,non-competitiveNMDAreceptor(NMDAr)antagonists,induce cognitive impairment and aggravate schizophrenia symptoms. In conscious rats, they produce an abnormal behavior associatedwithapeculiarbrainstatecharacterizedbyincreasedsynchronizationinongoingc(30–80Hz)oscillationsinthe frontoparietal (sensorimotor) electrocorticogram (ECoG). This study investigated whether NMDAr antagonists-induced aberrantcoscillationsarecorrelatedwithlocomotionanddependentonhyperlocomotion-relatedsensorimotorprocessing. This also implied to explore the contribution of intracortical and subcortical networks in the generation of these pathophysiologicalECoGcoscillations. Methodology/PrincipalFindings:Quantitativelocomotiondatacollectedwithacomputer-assistedvideotrackingsystem incombinationwithECoGrevealedthatketamineandMK-801inducehighlycorrelatedhyperlocomotionandaberrantc oscillations.Thisabnormalchyperactivitywasrecordedoverthefrontal,parietalandoccipitalcortices.ECoGconducted under diverse consciousness states (with diverse anesthetics) revealed that NMDArantagonists dramatically increase the powerofbasalcoscillations.PairedECoGandintracorticallocalfieldpotentialrecordingsshowedthattheECoGmainly reflectscoscillationsrecordedinunderlyingintracorticalnetworks.Inaddition,multisiterecordingsrevealedthatNMDAr antagonists dramatically enhance the amo