No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-C in Absence of DNA 英文参考文献.docVIP

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No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-C in Absence of DNA 英文参考文献.doc

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No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-C in Absence of DNA 英文参考文献

NoInteractionofBarrier-to-AutointegrationFactor(BAF) withHIV-1MA,Cone-RodHomeobox(Crx)orMAN1-Cin AbsenceofDNA YingHuang1,MengliCai2,G.MariusClore2,RobertCraigie1* 1LaboratoryofMolecularBiology,NationalInstituteofDiabetesandDigestiveandKidneyDiseases,NationalInstitutesofHealth,Bethesda,Maryland,UnitedStatesof America,2LaboratoryofChemicalPhysics,NationalInstituteofDiabetesandDigestiveandKidneyDiseases,NationalInstitutesofHealth,Bethesda,Maryland,United StatesofAmerica Abstract Barrier-to-autointegrationfactorisacellularproteinthatprotectsretroviralDNAfromautointegration.Itscellularroleisnot wellunderstood,butgeneticstudiesshowthatitisessentialanddepletionorknockoutresultsinlethalnucleardefects.In addition to binding DNA, BAF interacts with the LEM domain, a domain shared among a family of lamin-associated polypeptides. BAFhasalso beenreportedtointeractwithseveral otherviralandcellular proteins suggestingthatthese interactionsmaybefunctionallyrelevant.Wefindthat,contrarytopreviousreports,BAFdoesnotinteractwithHIV-1MA, cone-rod homeobox (Crx) or MAN1-C. The reported interactions can be explained by indirect association through DNA binding and are unlikely to be biologically relevant. A mutation that causes a premature aging syndrome lies on the previouslyreportedMAN1-CbindingsurfaceofBAF.TheabsenceofdirectbindingofBAFtoMAN1-Celiminatesdisruption ofthisinteractionasthecauseoftheprematureagingphenotype. Citation: Huang Y, Cai M, Clore GM, Craigie R(2011) No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-CinAbsenceofDNA.PLoSONE6(9):e25123.doi:10.1371/journal.pone.0025123 Editor:Jean-LucE.P.H.Darlix,InstitutNationaldelaSante′ etdelaRechercheMe′dicale, France ReceivedJuly27,2011;AcceptedAugust25,2011;PublishedSeptember22,2011 Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyonefor anylawfulpurpose.Theworkismadeavailableunde