- 1、本文档共2页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Nonhuman Primate Models for SARS 英文参考文献
respPectives
Nonhuman Primate Models for SARS
Bart L. Haagmans, Albert D. M. E. Osterhaus
*
S
evere acute respiratory
syndrome (SARS) ?rst emerged
in Guangdong Province, the
Animal Models for SARS
Development of animal models for
SARS-CoV infection of humans is of
utmost importance to elucidate the
pathogenesis of SARS and to develop
intervention strategies against the
infection. A wide range of animal
species is susceptible to experimental
infection with SARS-CoV, including
rodents (mice and hamsters),
carnivores (ferrets and cats), and
nonhuman primates (cynomolgus and
rhesus macaques, common marmosets,
and African green monkeys) [3–11].
Adult mice infected with varying
People’s Republic of China, in
November 2002. The disease was
characterised by a rapidly progressive
atypical pneumonia [1]. In addition
to other pathogens, a coronavirus not
previously discovered was identi?ed
in patients with SARS. Reproduction
of a similar disease in cynomolgus
macaques with this virus completed
Koch’s postulates, implicating SARS
coronavirus (SARS-CoV) as the
aetiologic agent [2,3].
doses of SARS-CoV in the respiratory
tract show no clinical signs of disease,
although the virus replicates in
ohgteanPesis
of SARS
In typical cases, which were largely
con?ned to adult and elderly
individuals, SARS presented
respiratory tissues, peaking early after
infection, with viral titres in the lungs
reaching relatively high levels. The
infection is accompanied by only mild
in?ammatory changes of the respiratory
tract. On the other hand, aged mice, as
well as hamsters and ferrets, do show
signs of clinical disease (weight loss and
ruf?ed fur), albeit, in most cases, in the
absence of the typical lung lesions seen
in humans with SARS [4–6].
In contrast, SARS-CoV inoculation
in the respiratory tract of cynomolgus
macaques causes infection of bronchial
epithelial cells, type-1 and type-2
pneumocytes at one to four days
postinfection, followed by extensive
type-2 pneumocyte hyperplasia in the
l
您可能关注的文档
- No Need for a Cognitive Map Decentralized Memory for Insect Navigation 英文参考文献.doc
- No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-C in Absence of DNA 英文参考文献.doc
- No More Free Drug Samples 英文参考文献.doc
- No Place for Predators 英文参考文献.doc
- No Seasonal Accumulation of Resistant P. falciparum when High-Dose Chloroquine Is Used 英文参考文献.doc
- Nobody Is Perfect ERP Effects Prior to Performance Errors in Musicians Indicate Fast Monitoring Processes 英文参考文献.doc
- No Need for Labels The Autofluorescence of Leishmania tarentolae Mitochondria and the Necessity of Negative Controls 英文参考文献.doc
- Nocturnal Hypoxia and Loss of Kidney Function 英文参考文献.doc
- Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin 英文参考文献.doc
- No Treatment versus 24 or 60 Weeks of Antiretroviral Treatment during Primary HIV Infection The Randomized Primo-SHM Trial 英文参考文献.doc
文档评论(0)