Observing metabolic functions at the genome scale 英文参考文献.docVIP

Open Access Re rch 2007SchwartzetVoal.lumesea8, Issue 6, Article R123 Observing metabolic functions at the genome scale ¤ ¤ Jean-Marc Schwartz *?, Claire Gaugain ?, Jose C Nacher*§, Antoine de Daruvar? and Minoru Kanehisa* Addresses: *Bioinformatics Center, Kyoto University, Uji, Kyoto 611-0011, Japan. ?Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. ?Centre de Bioinformatique de Bordeaux, Université Bordeaux 2, 33076 Bordeaux, France. §Department of Complex Systems, Future University, Hakodate, Hokkaido 041-8655, Japan. ¤ These authors contributed equally to this work. Correspondence: Jean-Marc Schwartz. Email: jean-marc.schwartz@manchester.ac.uk Published: 26 June 2007 Received: 21 March 2007 Revised: 30 May 2007 Accepted: 26 June 2007 Genome Biology 2007, 8:R123 (doi:10.1186/gb-2007-8-6-r123) The electronic version of this article is the complete one and can be found online at /2007/8/6/R123 ? 2007 Schwartz et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Genome-scalescpaleA.m/podularanalysisapproacofh imetabolisms presented that allows the observation of the transcriptional activity of metabolic functions at the genome Abstract Background: High-throughput techniques have multiplied the amount and the types of available biological data, and for the first time achieving a global comprehension of the physiology of biological cells has become an achievable goal. This aim requires the integration of large amounts of heterogeneous data at different scales. It is notably necessary to extend the traditional focus on genomic data towards a truly functional focus, where the activity of cells is described in terms of actual metabolic processes performing the functio