Nutraceutical Approach for Preventing Obesity-Related Colorectal and Liver Carcinogenesis 英文参考文献.docVIP
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Nutraceutical Approach for Preventing Obesity-Related Colorectal and Liver Carcinogenesis 英文参考文献
Int. J. Mol. Sci. 2012, 13, 579-595; doi:10.3390/ijmOPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Nutraceutical Approach for Preventing Obesity-Related
Colorectal and Liver Carcinogenesis
Masahito Shimizu 1,*, Masaya Kubota 1, Takuji Tanaka 2 and Hisataka Moriwaki 1
1
Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan;
E-Mails: samurai0201@yahoo.co.jp (M.K.); hmori@gifu-u.ac.jp (H.M.)
2
The Tohkai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP),
Gifu 500-8285, Japan; E-Mail: takutt@toukaisaibou.co.jp
* Author to whom correspondence should be addressed; E-Mail: shimim-gif@umin.ac.jp;
Tel.: +81-58-230-6313; Fax: +81-58-230-6310.
Received: 28 November 2011; in revised form: 20 December 2011 / Accepted: 27 December 2011 /
Published: 5 January 2012
Abstract: Obesity and its related metabolic abnormalities, including insulin resistance,
alterations in the insulin-like growth factor-1 (IGF-1)/IGF-1 receptor (IGF-1R) axis, and
the state of chronic inflammation, increase the risk of colorectal cancer (CRC) and
hepatocellular carcinoma (HCC). However, these findings also indicate that the metabolic
disorders caused by obesity might be effective targets to prevent the development of
CRC and HCC in obese individuals. Green tea catechins (GTCs) possess anticancer and
chemopreventive properties against cancer in various organs, including the colorectum and
liver. GTCs have also been known to exert anti-obesity, antidiabetic, and anti-inflammatory
effects, indicating that GTCs might be useful for the prevention of obesity-associated
colorectal and liver carcinogenesis. Further, branched-chain amino acids (BCAA), which
improve protein malnutrition and prevent progressive hepatic failure in patients with
chronic liver diseases, might be also effective for the suppression
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