Nucleolin Is Required for DNA Methylation State and the Expression of rRNA Gene Variants in Arabidopsis thaliana 英文参考文献.docVIP
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Nucleolin Is Required for DNA Methylation State and the Expression of rRNA Gene Variants in Arabidopsis thaliana 英文参考文献
NucleolinIsRequiredforDNAMethylationStateandthe
ExpressionofrRNAGeneVariantsinArabidopsisthaliana
Fre′de′ricPontvianne1,2,MohamedAbou-Ellail1,JulienDouet3,PascaleComella1,IsabelMatia4 ,Chinmayi
Chandrasekhara2,AnneDeBures1,ToddBlevins2,RichardCooke1,FranciscoJ.Medina4 ,Sylvette
Tourmente3,CraigS.Pikaard2,JulioSa′ez-Va′squez1*
1UMR5096CNRS-IRD-UniversitydePerpignan,Perpignan,France,2DepartmentofBiologyandDepartmentofMolecularandCellularBiochemistry,IndianaUniversity,
Bloomington, Indiana, United States of America, 3UMR CNRS 6247, INSERM U931, University Blaise Pascal, Aubie`re, France, 4Centro de Investigaciones Biolo′gicas,
ConsejoSuperiordeInvestigacionCient?′ficas,Madrid,Spain
Abstract
Ineukaryotes, 45SrRNAgenesarearrangedintandemarraysincopynumbersrangingfromseveralhundredtoseveral
thousandinplants.Althoughitisclearthatnotallcopiesaretranscribedundernormalgrowthconditions,themolecular
basis controlling the expression of specific sets of rRNA genes remains unclear. Here, we report four major rRNA gene
variantsinArabidopsisthaliana.Interestingly,whiletranscriptionofoneoftheserRNAvariantsisinduced,theothersare
either repressed or remain unaltered in A. thaliana plants with a disrupted nucleolin-like protein gene (Atnuc-L1).
Remarkably, the most highly represented rRNA gene variant, which is inactive in WT plants, is reactivated in Atnuc-L1
mutants. We show that accumulated pre–rRNAs originate from RNA Pol I transcription and are processed accurately.
Moreover,weshowthatdisruptionoftheAtNUC-L1geneinduceslossofsymmetricalDNAmethylationwithoutaffecting
histoneepigeneticmarksatrRNAgenes.Collectively,thesedatarevealanovelmechanismforrRNAgenetranscriptional
regulation in which the nucleolin protein plays a major role in controlling active and repressed rRNA gene variants in
Arabidopsis.
Citation:PontvianneF,Abou-EllailM,DouetJ,ComellaP,MatiaI,etal.(2010)NucleolinIsRequiredforDNAMethylationStateandtheExpressionofrRNAGene
VariantsinArabidopsisthaliana.PLoSGenet6(11):e100
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