Nucleolar Proteins Suppress Caenorhabditis elegans Innate Immunity by Inhibiting p53CEP-1 英文参考文献.docVIP
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Nucleolar Proteins Suppress Caenorhabditis elegans Innate Immunity by Inhibiting p53CEP-1 英文参考文献
NucleolarProteinsSuppressCaenorhabditiselegansInnate
ImmunitybyInhibitingp53/CEP-1
LauraE.Fuhrman1,AjayKumarGoel1,JasonSmith2,KevinV.Shianna2,AlejandroAballay1*
1DepartmentofMolecularGeneticsandMicrobiology,DukeUniversityMedicalCenter;Durham,NorthCarolina,UnitedStatesofAmerica,2InstituteforGenomeSciences
Policy,DukeUniversity,Durham,NorthCarolina,UnitedStatesofAmerica
Abstract
Thetumorsuppressorp53hasbeenimplicatedinmultiplefunctionsthatplaykeyrolesinhealthanddisease,including
ribosomebiogenesis,controlofaging,andcellcycleregulation.Ageneticscreenfornegativeregulatorsofinnateimmunity
inCaenorhabditiselegansledtotheidentificationofamutationinNOL-6,anucleolarRNA-associatedprotein(NRAP),which
isinvolvedinribosomebiogenesisandconservedacrosseukaryoticorganisms.MutationorsilencingofNOL-6andother
nucleolarproteinsresultsinanenhancedresistancetobacterialinfections.Afull-genomemicroarrayanalysisonanimals
withalteredimmunefunctionduetomutationinnol-6showsincreasedtranscriptionallevelsofgenesregulatedbyap53
homologue, CEP-1. Further studies indicate that the activation of innate immunity by inhibition of nucleolar proteins
requiresp53/CEP-1anditstranscriptionaltargetSYM-1.Sincenucleoliandp53/CEP-1areconserved,ourresultsrevealan
ancientimmunemechanismbywhichthenucleolusmayregulateimmuneresponsesagainstbacterialpathogens.
Citation:FuhrmanLE,GoelAK,SmithJ,ShiannaKV,AballayA(2009)NucleolarProteinsSuppressCaenorhabditiselegansInnateImmunitybyInhibitingp53/CEP-1.PLoS
Genet5(9):e1000657.doi:10.1371/journal.pgen.1000657
Editor:StuartK.Kim,StanfordUniversityMedicalCenter,UnitedStatesofAmerica
ReceivedMay15,2009;AcceptedAugust20,2009;PublishedSeptember18,2009
Copyright: ? 2009 Fuhrman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:ThisworkissupportedbyNIHGM070977.Thefundershadnoroleinstudydesign,da
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