On the Analysis of Genome-Wide Association Studies in Family-Based Designs A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies 英文参考文献.docVIP
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On the Analysis of Genome-Wide Association Studies in Family-Based Designs A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies 英文参考文献
OntheAnalysisofGenome-WideAssociationStudiesin
Family-BasedDesigns:AUniversal,RobustAnalysis
ApproachandanApplicationtoFourGenome-Wide
AssociationStudies
SunghoWon1,2,JemmaB.Wilk3,RasikaA.Mathias4,ChristopherJ.O’Donnell5,6,EdwinK.Silverman7,8,9
KathleenBarnes10,GeorgeT.O’Connor11,ScottT.Weiss7,9,12,ChristophLange9.12,13
,
*
1Department of Statistics, Chung-Ang University, Seoul, Korea, 2Research Center for Data Science, Chung-Ang University, Seoul, Korea, 3Department of Neurology,
Boston University School of Medicine, Boston, Massachusetts, United States of America, 4Genometrics Section, Inherited Disease Research Branch, National Human
GenomeResearch Institute, NationalInstitutes ofHealth, Baltimore, Maryland, UnitedStates ofAmerica, 5NationalHeart,Lung, and BloodInstitute and Framingham
HeartStudy,Bethesda,Maryland,UnitedStatesofAmerica,6CardiologyDivision,MassachusettsGeneralHospital,HarvardMedicalSchool,Boston,Massachusetts,United
States of America, 7Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 8Division of
PulmonaryandCriticalCareMedicine,BrighamandWomen’sHospital,Boston,Massachusetts,UnitedStatesofAmerica,9HarvardMedicalSchool,Boston,Massachusetts,
UnitedStatesofAmerica,10DepartmentofMedicine,SchoolofMedicine,JohnsHopkinsUniversity,Baltimore,Maryland,UnitedStatesofAmerica,11PulmonaryCenter,
Boston University School of Medicine, Boston, Massachusetts, United States of America, 12Center for Genomic Medicine, Brigham and Women’s Hospital, Boston,
Massachusetts,UnitedStatesofAmerica,13DepartmentofBiostatistics,HarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica
Abstract
Forgenome-wideassociationstudiesinfamily-baseddesigns,weproposeanew,universallyapplicableapproach.Thenew
test statistic exploits all available information about the association, while, by virtue of its design, itmaintains the same
robustnessagainstpopulationadmixtureastraditionalfamily-basedapproach
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