Open-source software accelerates bioinformatics 英文参考文献.docVIP

Meeting report Open-source software accelerates bioinformatics John Quackenbush Address: The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. E-mail: johnq@ Published: 1 September 2003 Genome Biology 2003, 4:336 The electronic version of this article is the complete one and can be found online at /2003/4/9/336 ? 2003 BioMed Central Ltd provide much richer and more complex information about A report on the Wellcome Trust/Cold Spring Harbor individual genes. Other resources, such as the University of Genome Informatics meeting, Cold Spring Harbor, USA, California Santa Cruz Genome Browser, have democratized 7-11 May 2003. genome annotation by allowing specialists from around the world to present their own view of genomic features. Reflect- ing the maturing of these utilities, however, the database The wide availability of genome sequence data has created a wealth of opportunities, most notably in the realm of func- tional genomics and proteomics. This quiet revolution in the biological sciences has been enabled by our ability to collect, manage, analyze, and integrate large quantities of data. In the process, bioinformatics has itself developed from some- thing considered to be little more than information manage- ment and the creation of sequence-search tools into a vibrant field encompassing both highly sophisticated data- base development and active pure and applied research pro- grams in areas far beyond the search for sequence homology. The nearly 250 participants at this meeting represented not only hard-core computational scientists but also laboratory biologists who are increasingly moving from being users of software to developing it themselves. sessions instead focused on other issues. Increasingly, we are coming to realize that protein-coding genes are not the only important transcribed sequences in the genome. Sam