Optic Nerve Head Quantification in Idiopathic Intracranial Hypertension by Spectral Domain OCT 英文参考文献.docVIP

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Optic Nerve Head Quantification in Idiopathic Intracranial Hypertension by Spectral Domain OCT 英文参考文献.doc

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Optic Nerve Head Quantification in Idiopathic Intracranial Hypertension by Spectral Domain OCT 英文参考文献

OpticNerveHeadQuantificationinIdiopathic IntracranialHypertensionbySpectralDomainOCT FalkoKaufhold1,EllaMariaKadas1,ChristophSchmidt2,HagenKunte3,JanHoffmann3, HannaZimmermann1,TimmOberwahrenbrock1,LutzHarms3,4,KonradPolthier5,AlexanderU.Brandt1., 1,4 . FriedemannPaul * 1NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charite′ – Universita¨tsmedizin Berlin and Max Delbru¨ck Center for Molecular Medicine,Berlin,Germany,2InstituteofNeuroradiology,Charite′ –Universita¨tsmedizinBerlin,Berlin,Germany,3DepartmentofNeurology,Charite′ –Universita¨tsmedizin Berlin,Berlin,Germany,4ClinicalandExperimentalMultipleSclerosisResearchCenter,Charite′ –Universita¨tsmedizin Berlin,Berlin,Germany,5MathematicalGeometry ProcessingGroup,FreieUniversita¨t Berlin,Berlin,Germany Abstract Objective:Toevaluate3Dspectraldomainopticalcoherencetomography(SDOCT)volumescansasatoolforquantification ofopticnervehead(ONH)volumeasapotentialmarkerfortreatmenteffectivenessanddiseaseprogressioninidiopathic intracranialhypertension(IIH). DesignandPatients:Cross-sectionalpilottrialcomparing19IIHpatientsandcontrolsmatchedforgender,ageandbody massindex.EachparticipantunderwentSDOCT.AcustomsegmentationalgorithmwasdevelopedtoquantifyONHvolume (ONHV)andheight(ONHH)in3Dvolumescans. Results:WhereasperipapillaryretinalnervefiberlayerthicknessdidnotshowdifferencesbetweencontrolsandIIHpatients, thenewlydeveloped3DparametersONHVandONHHwereabletodiscriminatebetweencontrols,treatedanduntreated patients.BothONHVandONHHmeasureswererelatedtolevelsofintracranialpressure(ICP). Conclusion:Ourfindingssuggest3DONHmeasuresasassessedbySDOCTaspotentialdiagnosticandprogressionmarkers inIIHandotherdisorderswithincreasedICP.SDOCTmaypromiseafastandeasydiagnosticalternativetorepeatedlumbar puncturesandcouldthereforeeasemonitoringoftreatmentordiseaseprogression. Citation:KaufholdF,KadasEM,SchmidtC,KunteH,HoffmannJ,etal.(2012)OpticNerveHeadQuantificationinIdiopathicIntracranialHypertensio