Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer 英文参考文献.docVIP

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Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer 英文参考文献.doc

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Overexpression of ribosome binding protein 1 (RRBP1) in breast cancer 英文参考文献

Telikicherlaetal.ClinicalProteomics2012,9:7 /content/9/1/7 CLINICAL PROTEOMICS RESEARCH OpenAccess Overexpressionofribosomebindingprotein1 (RRBP1)inbreastcancer DeepthiTelikicherla1,2,ArivusudarMarimuthu1,ManojKumarKashyap1,YLRamachandra2,SujathaMohan1,3, JuanCarlosRoa4,JagadeeshaMaharudraiah1,5,6* andAkhileshPandey7,8,9,10,11* *Correspondence:jagadeesha@ ;pandey@jhmi. Abstract edu Themoleculareventsthatleadtomalignanttransformationandsubsequent metastasisofbreastcarcinomaincludealterationsinthecellsatgenome, 1InstituteofBioinformatics, InternationalTechPark,Bangalore 560066,India transcriptomeandproteomelevels.Inthisstudy,weusedpubliclyavailablegene expressiondatabasestoidentifythosecandidategeneswhichareupregulatedatthe mRNAlevelinbreastcancersbuthavenotbeensystematicallyvalidatedatthe proteinlevel.Basedonanextensiveliteraturesearch,weidentifiedribosomebinding protein1(RRBP1)asacandidatethatisupregulatedatthemRNAlevelinfive differentstudiesbutitsproteinexpressionhadnotbeeninvestigated. 5DepartmentofPathologyand LaboratoryMedicine,IconHospitals, Bangalore560027,India Fulllistofauthorinformationis availableattheendofthearticle Immunohistochemicallabelingofbreastcancertissuemicroarrayswascarriedoutto determinetheexpressionofRRBP1inalargepanelofbreastcancers.Wefoundthat RRBP1wasoverexpressedin84%(177/219)ofbreastcarcinomacasestested.The subcellularlocalizationofRRBP1wasmainlyobservedtobeinthecytoplasmwith intensestainingintheperinuclearregion.OurfindingssuggestthatRRBP1isan interestingmoleculethatcanbefurtherstudiedforitspotentialtoserveasabreast cancerbiomarker.Thisstudyalsodemonstrateshowtheintegrationofbiological datafromavailableresourcesinconjunctionwithsystematicevaluationapproaches canbesuccessfullyappliedtoclinicalproteomics. Keywords:Breastneoplasms,ES130,p180,180kDaribosomereceptorhomolog, Endoplasmicreticulummembraneprotein,Immunohistochemistry,Biomarker,Early detection Background Breast cancer is the mostprevalent cancer in women and is responsible for