Overview of the biology of type I interferons 英文参考文献.docVIP

Kalliolias and Ivashkiv Arthritis Research Therapy 2010, 12(Suppl 1):S1 /content/12/S1/S1 RE VIE W Overview of the biology of type I interferons George D Kalliolias and Lionel B Ivashkiv * 1 1,2 arma men tarium and are indicated for several disease entities [2,8]. Firstly, type I interferons are widely used for the treatment of chronic viral infections, mainly by hepatitis B virus and hepatitis C virus [2]. Several major break throughs in the ? eld of interferon research have established the notion that type I interferons are not only antiviral peptides but pleiotropic cytokines. Along these lines it was observed that type I interferons can inhibit growth of some tumors by suppressing prolifera tion and inducing cell apoptosis, inhibiting angiogenesis, increas- ing immunogenicity of tumor cells and activating cyto- Abstract Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be anti-in?ammatory and tissue protective or can be proin?ammatory and promote autoimmunity. Along these lines, the activation of type I interferon pathways is e?ective in suppressing disease activity in patients with multiple sclerosis and in animal models of arthritis and colitis, while there is an expectation that blockade of the same pathways will be bene?cial in the treatment of patients with systemic lupus erythematosus. toxicity against tumor cells [2]. In this context, IFNα is 2 used in some treatment regimens for malignancies including chronic B-cell (hairy) leukemia, chronic myelo- genous leukemia, myeloma, lymphomas, melanoma, renal-cell and bladder carcinoma and Kaposi’s sarcoma [2,8]. Finally, recognition of modulatory e? ects of type I interferons has led to the discovery that