胃黏膜胆色素染色对原发性病理性十二指肠胃反流的诊断价值.docVIP

　　胃黏膜胆色素染色对原发性病理性十二指肠胃反流的诊断价值 作者：韩俊岭 姜东春 韩莹 杨艳红 任凤杰 曲磊红 郑岳 姚树坤 【摘要】 目的 探讨胃黏膜胆色素染色对原发性病理性十二指肠胃反流的诊断价值。方法 86例原发性病理性十二指肠胃反流病人和 42例正常志愿者对照胃黏膜胆色素染色后进行定量分析，应用便携式胆汁监测仪(Bilitec 2000)监测胃内24 h胆汁反流情况，以胆红素吸收值≥0.25的时间百分比作为评价胆汁反流程度的主要观察指标。结果 病例组中胃窦、胃角和胃体部黏膜胆色素沉积显著高于正常对照组(P＜0.01)，胃窦和胃角部黏膜胆色素沉积显著高于胃体部(P＜0.01)；病例组中胃窦和胃角部黏膜胆色素沉积与胃窦和胃角部黏膜新悉尼系统病理积分均呈正相关(r=0.521,P=0.000和r=0.468,P=0.002)，胃体部黏膜胆色素沉积与胃体部黏膜新悉尼系统病理积分无相关性(r=0.185,P=0.236)；病例组中胃窦和胃角部黏膜胆色素沉积与胆红素吸收值≥0.25的时间百分比均呈正相关(r=0.458,P=0.002和r=0.334,P=0.028)，胃体部黏膜胆色素沉积与胆红素吸收值≥0.25的时间百分比无相关性(r=0.092,P=0.556)。结论 胃窦部黏膜胆色素染色能够反映胆汁反流程度，并与黏膜损伤程度呈正相关，对原发性病理性十二指肠胃反流有诊断价值，可用于原发性病理性十二指肠胃反流的辅助诊断。 【关键词】 原发性病理性十二指肠胃反流；胆汁监测；胆色素染色 　　【Abstract】 Objective To study the value of porphobilin staining of gastric mucosa on diagnosis of primary pathological duodenogastric reflux. Methods Porphobilin staining of gastric mucosa of 86 cases in primary pathological duodenogastric reflux group and 42 cases in normal group easured by quantitative diagnosis. 24 hour intragastric bilirubin monitoring easured by using Bilitec 2000 and time percentage of bilirubin absorbance ≥0.25 ucosa of gastric antrum, gastric anguli and gastric body in primary pathological duodenogastric reflux group al group (P＜0.01). The deposition of porphobilin in mucosa of gastric antrum and gastric anguli ary pathological duodenogastric reflux group (P＜0.01). The deposition of porphobilin in mucosa of gastric antrum and gastric anguli pathological scores of gastric antrum and gastric anguli in primary pathological duodenogastric reflux group (r=0.521, P=0.000 and r=0.468, P=0.002). The deposition of porphobilin in mucosa of gastric body pathological scores of gastric body in primary pathological duodenogastric reflux group (r=0.185, P=0.236).The deposition of porphobilin in mucosa of gastric antrum and gastric anguli e percentage of bilirubin absorbance ≥0.25 in primary pathological duodenogastric reflux group (r=0.458, P=0.002 and r=0.334,P=0.028). The deposition of porphobilin in muco