Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease 英文参考文献.docVIP
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Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease 英文参考文献
Pharmaceuticals 2010, 3, 158-187; doi:10.3390/ph3010158
OPEN ACCESS
Pharmaceuticals
ISSN 1424–8247
/journal/pharmaceuticals
Review
Oxidative Stress Induced Mitochondrial Failure and Vascular
Hypoperfusion as a Key Initiator for the Development of
Alzheimer Disease
Gjumrakch Aliev 1,2,3,*, Hector H. Palacios 4, Eldar Gasimov 5, Mark E. Obrenovich 6,
Ludis Morales 2, Jerzy Leszek 7, Valentin Bragin 3, Arturo Solís Herrera 8 and
Dmitry Gokhman 9
1
School of Health Science and Healthcare Administration, University of Atlanta, 6685 Peachtree
Industrial Blvd., Atlanta, Georgia, 30360, USA
2
Department of Nutrition and Biochemistry, Faculty of Sciences, Javeriana University, Bogotà D.C.,
Colombia
3
Stress Relief and Memory Training Center, Brooklyn, New York, NY 11235, USA
4
Department of Biology, College of Sciences, University of Texas at San Antonio, One UTSA
Circle, San Antonio, TX 78249–1664, USA
5
Department of Cytology, Histology and Embryology, Azerbaijan Medical University, 25 Street
Bakhikhanov, Baku AZ10 25, Azerbaijan
6
Department of Pathology, School of Medicine, Case Western Reserve University, WRB 5301,
Cleveland, Ohio, 44106, USA
7
Department of Psychiatry, Wroclaw Medical University, 25 St. Kraszewskiego, Wroclaw, 50–229,
Poland
8
Dirección de Investigación y desarrollo, Centro de Estudios de la Fotosíntesis Humana, S.C. López
Velarde 108 y 109, Centro, Aguascalientes, Aguascalientes, 20000, México
9
Department of Mathematics, College of Sciences, University of Texas at San Antonio, One UTSA
Circle, San Antonio, TX 78249, USA
* Author to whom correspondence should be addressed; E-Mail: aliev03@ or
GAliev@UofA.edu; Tel.: +1-440-263-7461.
Received: 28 November 2009; in revised form: 11 January 2010 / Accepted: 14 January 2010 /
Published: 19 January 2010
Abstract: Mitochondrial dysfunction may be a principal underlying event in aging,
including age-associated brain degeneration. Mitochondria provide energy for basic
metabo
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