Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF-KappaB Translocation 英文参考文献.docVIP

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Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF-KappaB Translocation 英文参考文献.doc

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Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF-KappaB Translocation 英文参考文献

Molecules 2011, 16, 2583-2598; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF-KappaB Translocation Shiau-Chuen Cheah 1,*, David R. Appleton 1,2, Sui-Ting Lee 1, May-Lynn Lam 3, A. Hamid A. Hadi 4 and Mohd. Rais Mustafa 1 1 Centre of Natural Products Drug Discovery (CENAR), Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: drappleton@ (D.R.A.); suiting87@.my (S.T.L.); rais@.my (M.R.M.) 2 Sime Darby Technology Centre, 1st Floor, Block B, UPM-MTDC Technology Centre III, UPM, Serdang 43400, Selangor, Malaysia 3 Cancer Research Initiatives Foundation (CARIF), 2nd Floor, Outpatient Centre, Sime Darby Medical Centre, 47500 Subang Jaya, Selangor Darul Ehsan, Malaysia; E-Mail: lammaylynn@ (M.-L.L.) 4 Centre of Natural Products Drug Discovery (CENAR), Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mail: ahamid@.my (A.H.A.H.) * Author to whom correspondence should be addressed; E-Mail: cheahsc@.my; Tel.: +603 Fax: +603 Received: 23 February 2011; in revised form: 03 March 2011 / Accepted: 11 March 2011 / Published: 21 March 2011 Abstract: In the present study we investigated the effects of panduratin A, isolated from Boesenbergia rotunda, on proliferation and apoptosis in A549 human non-small cell lung cancer cells. Cell proliferation and induction of apoptosis was determined by the real-time cellular analyzer (RTCA), MTT assay and High Content Screening (HCS). The RTCA assay indicated that panduratin A exhibited cytotoxicity, with an IC50 value of 4.4 μg/mL (10.8 μM). Panduratin A arrested cancer cells labeled with bromodeoxyuridine (BrdU) and phospho-Histone H3 in the mitotic phase. The cytotoxic effects of panduratin A were found to be accompanied by a dos