Pathological mechanisms of skin homing T cells in atopic dermatitis 英文参考文献.docVIP

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Pathological mechanisms of skin homing T cells in atopic dermatitis 英文参考文献.doc

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Pathological mechanisms of skin homing T cells in atopic dermatitis 英文参考文献

INVITEDREVIEWARTICLE PathologicalMechanismsofSkinHomingTCellsin AtopicDermatitis MartaFerran,MD,1 andLuisF.Santamaria-Babi,PhD1,2 primaryorsecondaryroleinthedefectivebarrierfunctionin Abstract: Skin in?ltration of circulating memory T cells with AD, it is known that T cells play an important role in the cutaneoustropismisconsideredoneofthepathologicmechanisms pathologicmechanismofAD.Thefactthatdrugsactingon in atopic dermatitis (AD). Skin-seeking circulating T lymphocytes immune-mediated mechanisms are the most effective treat- canbeidenti?edbytheirexpressionofthecutaneouslymphocyte- ments for AD at the moment (corticosteroids and immuno- associatedantigenonthecellsurface.Recentstudieshavecontrib- modulators such as tacrolimus or pimecrolimus) supports uted useful new information about the function and recirculation theirpathogenicrole. propertiesofthosecellsinADpatients.Thisreviewintegratesthe latest?ndingsonperipheralcutaneouslymphocyte-associatedanti- genmemoryTcellsinADandhighlightstherelevanceofthiscell type and its importance to our understanding of the pathologic mechanismsofAD. CIRCULATINGMEMORY CLA ?TLYMPHOCYTES Circulating memory cutaneous lymphocyte-associated antigen(CLA)?Tcellsparticipateinthein?ammatoryreac- tion produced during the initiation of AD lesion.4–6 studies,reviewedbelow,supporttheroleofCLA?Tcellsas KeyWords:homing,CLA,skin,atopiceczema,Tcell (WAOJournal2010;3:44–47) Recent one of the pathologic mechanisms in AD, and the reduced innateimmuneresponseandabnormalskinbarrierfunction. 2 CLA, a surface glycoprotein expressed in 15% of peripheral blood lymphocytes, acts as a skin homing mole- INTRODUCTION topic dermatitits (AD) is the most common childhood skin disease, with a steadily increasing prevalence over recentdecades.Characterizedbychronicandrelapsing?ares ofintrinsicorextrinsiceczema,ADisconsideredtobepart of the atopic state, which includes asthma, allergic rhinitis, allergicconjunctivitis,andfoodallergies.ADnormallypre- 1 cedes all o