Perioperative factors determine outcome after surgery for severe acute pancreatitis 英文参考文献.docVIP

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Perioperative factors determine outcome after surgery for severe acute pancreatitis 英文参考文献.doc

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Perioperative factors determine outcome after surgery for severe acute pancreatitis 英文参考文献

Available online /content/8/6/R504 Research Open Access December 2004 Vol 8 No 6 Perioperative factors determine outcome after surgery for severe acute pancreatitis Jan J De Waele1, Eric Hoste1, Stijn I Blot2, Uwe Hesse3, Piet Pattyn3, Bernard de Hemptinne3, Johan Decruyenaere1, Dirk Vogelaers4 and Francis Colardyn1 1Intensivist, Intensive Care Unit, Ghent University Hospital, Gent, Belgium 2Researcher, Intensive Care Unit, Ghent University Hospital, Gent, Belgium 3Surgeon, Intensive Care Unit, Ghent University Hospital, Gent, Belgium 4Infectious Diseases Consultant, Department of Surgery, Ghent University Hospital, Gent, Belgium Corresponding author: Jan J De Waele, jan.dewaele@UGent.be Received: 15 July 2004 Critical Care 2004, 8:R504-R511 (DOI 10.1186/cc2991) This article is online at: /content/8/6/R504 Revisions requested: 3 September 2004 Revisions received: 22 September 2004 Accepted: 7 October 2004 ? 2004 De Waele et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/ licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Published: 2 November 2004 Abstract Introduction There is evidence that postponing surgery in critically ill patients with severe acute pancreatitis (SAP) leads to improved survival, but previous reports included patients with both sterile and infected pancreatic necrosis who were operated on for various indications and with different degrees of organ dysfunction at the moment of surgery, which might be an important bias. The objective of this study is to analyze the impact of timing of surgery and perioperative factors (severity of organ dysfunction and microbiological status of the necrosis) on mortality in intensive care unit (ICU) patients undergoing surgery for SAP. Methods We retrospectively (January 1994 to March 2003) analy