Performance of N-terminal-pro-B-type natriuretic peptide in critically ill patients a prospective observational cohort study 英文参考文献.docVIP

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Performance of N-terminal-pro-B-type natriuretic peptide in critically ill patients a prospective observational cohort study 英文参考文献.doc

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Performance of N-terminal-pro-B-type natriuretic peptide in critically ill patients a prospective observational cohort study 英文参考文献

Available online /content/12/6/R137 Research Open Access Vol 12 No 6 Performance of N-terminal-pro-B-type natriuretic peptide in critically ill patients: a prospective observational cohort study Isaline Coquet1,2, Michael Darmon1, Jean-Marc Doise2, Michel Degrès3, Bernard Blettery2, Beno?t Schlemmer1,4, Philippe Gambert3 and Jean-Pierre Quenot2 1Medical Intensive Care Unit, Saint-Louis University Hospital, AP-HP, 1 Avenue Claude Vellefaux, Paris, 75010, France 2Medical Intensive Care Unit, Dijon University Hospital, 1 boulevard Jeanne dArc, Dijon, 21079 Dijon cedex, France 3Biochemistry Laboratory, Dijon University Hospital, 1 boulevard Jeanne dArc, Dijon, 21079 Dijon cedex, France 4Université Paris-7 Paris-Diderot, UFR de Médecine, 75010 Paris, France Corresponding author: Michael Darmon, michael.darmon@sls.aphp.fr Received: 6 Aug 2008 Revisions requested: 3 Sep 2008 Revisions received: 11 Sep 2008 Accepted: 6 Nov 2008 Published: 6 Nov 2008 Critical Care 2008, 12:R137 (doi:10.1186/cc7110) This article is online at: /content/12/6/R137 ? 2008 Coquet et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The purpose of this study was to assess the accuracy of N-terminal-pro-B-type natriuretic peptide (NT- proBNP) as a diagnostic tool to recognize acute respiratory failure of cardiac origin in an unselected cohort of critically ill patients. 0.0001). When evaluating the performance of NT-proBNP concentrations to detect cardiac dysfunction, the area under the receiver operating characteristic (ROC) curve was 0.76 (95% confidence interval (CI) 0.69 to 0.83). In addition, a stepwise logistic regression model revealed that NT-proBNP (odds ratio (OR) = 1.01 per 100 ng/L