PFGE, Lior serotype, and antimicrobial resistance patterns among Campylobacter jejuni isolated from travelers and US military personnel with acute diarrhea in Thailand, 1998-2003 英文参考文献.docVIP

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PFGE, Lior serotype, and antimicrobial resistance patterns among Campylobacter jejuni isolated from travelers and US military personnel with acute diarrhea in Thailand, 1998-2003 英文参考文献.doc

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PFGE, Lior serotype, and antimicrobial resistance patterns among Campylobacter jejuni isolated from travelers and US military personnel with acute diarrhea in Thailand, 1998-2003 英文参考文献

Serichantalergsetal.GutPathogens2010,2:15 /content/2/1/15 RESEARCH OpenAccess PFGE,Liorserotype,andantimicrobialresistance patternsamongCampylobacterjejuniisolated fromtravelersandUSmilitarypersonnelwith acutediarrheainThailand,1998-2003 OralakSerichantalergs1,2*,PiyaratPootong1,AndersDalsgaard2,LadapornBodhidatta1,PatriciaGuerry3, DavidRTribble4,SinnAnuras5,CarlJMason1 Abstract Background:Campylobacterjejuniisamajorcauseofgastroenteritisworldwide.InThailand,severalstrainsof C.jejunihavebeenisolatedandidentifiedasmajordiarrhealpathogensamongadulttravelers.Tostudythe epidemiologyofC.jejuniinadulttravelersandU.S.militarypersonnelwithacutediarrheainThailandfrom 1998-2003,strainsofC.jejuniwereisolatedandphenotypicallyidentified,serotyped,testedforantimicrobial susceptibility,andcharacterizedusingpulsed-fieldgelelectrophoresis(PFGE). Results:Atotalof312C.jejuniisolateswereobtainedfromtravelers(n=46)andU.S.militarypersonnel(n=266) inThailandwhowereexperiencingacutediarrhea.Nalidixicacidandciprofloxacinresistancewasobservedin 94.9%and93.0%oftheisolates,respectively.From2001-2003,resistancetotetracycline(81.9%),trimethoprim- sulfamethoxazole(57.9%),ampicillin(28.9%),kanamycin(5.9%),sulfisoxazole(3.9%),neomycin(2.0%),and streptomycin(0.7%)wasobserved.CombinedPFGEanalysisshowedconsiderablegeneticdiversityamongthe C.jejuniisolates;however,fourPFGEclustersincludedisolatesfromthemajorLiorserotypes(HL:36,HL:11,HL:5, andHL:28).ThePFGEanalysislinkedindividualC.jejuniclonesthatwereobtainedatU.S.militaryexerciseswith specificantimicrobialresistancepatterns. Conclusions:Insummary,mosthumanC.jejuniisolatesfromThailandweremulti-resistanttoquinolonesand tetracycline.PFGEdetectedspatialandtemporalC.jejuniclonalityresponsibleforthecommonsourcesof Campylobactergastroenteritis. Background techniques such as RFLP, RAPD, PFGE, AFLP, and Campylobacterjejuniisamajorcauseofgastroenteritis MLSThavealsobeenappliedtoC.jejuniisolatecharac- worldwide,especiallyinchildren,travelers,andmilitary