Pharmacokinetics of epinephrine in patients with septic shock modelization and interaction with endogenous neurohormonal status 英文参考文献.docVIP

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Pharmacokinetics of epinephrine in patients with septic shock modelization and interaction with endogenous neurohormonal status 英文参考文献.doc

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Pharmacokinetics of epinephrine in patients with septic shock modelization and interaction with endogenous neurohormonal status 英文参考文献

Available online /content/13/4/R120 Research Open Access Vol 13 No 4 Pharmacokinetics of epinephrine in patients with septic shock: modelization and interaction with endogenous neurohormonal status Imad Abboud1, Nicolas Lerolle1, Saik Urien2, Jean-Marc Tadié1, Fran?oise Leviel3, Jean- Yves Fagon1 and Christophe Faisy1 1Medical Intensive Care Unit, H?pital Européen Georges Pompidou, Assistance Publique-H?pitaux de Paris, Université Paris – Descartes, Paris, France 2E.A. 3620, CIC-0109 Cochin-Necker Paris Descartes, Unité de Recherche Clinique, Tarnier Hospital, Assistance Publique-H?pitaux de Paris, Université Paris – Descartes, Paris, France 3Department of Physiology, H?pital Européen Georges Pompidou, Assistance Publique-H?pitaux de Paris, Université Paris – Descartes, Paris, France Corresponding author: Nicolas Lerolle, nilerolle@chu-angers.fr Received: 20 Mar 2009 Revisions requested: 24 Apr 2009 Revisions received: 26 Jun 2009 Accepted: 21 Jul 2009 Published: 21 Jul 2009 Critical Care 2009, 13:R120 (doi:10.1186/cc7972) This article is online at: /content/13/4/R120 ? 2009 Abboud et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction In septic patients, an unpredictable response to epinephrine may be due to pharmacodynamic factors or to non- linear pharmacokinetics. The purpose of this study was to Results Plasma epinephrine concentrations ranged from 4.4 to 540 nmol/L at steady-state infusion (range 0.1 to 7 mg/hr; 0.026 to 1.67 μg/kg/min). A one-compartment model investigate the pharmacokinetics of epinephrine and its adequately described the data. Only body weight (BW) and New Simplified Acute Physiologic Score (SAPSII) at intensive unit admission significant