- 1、本文档共6页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
- 5、该文档为VIP文档,如果想要下载,成为VIP会员后,下载免费。
- 6、成为VIP后,下载本文档将扣除1次下载权益。下载后,不支持退款、换文档。如有疑问请联系我们。
- 7、成为VIP后,您将拥有八大权益,权益包括:VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 8、VIP文档为合作方或网友上传,每下载1次, 网站将根据用户上传文档的质量评分、类型等,对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
Polymorphism in regulatory gene sequences 英文参考文献
/2000/2/1/comment/2001.1
Opinion
Polymorphism in regulatory gene sequences
N A Mitchison
Address: Department of Immunology, Windeyer Institute of Medical Science, University College London Medical School, Cleveland Street,
London W1P 6DB, UK. E-mail: n.mitchison@ucl.ac.uk
Published: 20 December 2000
GenomeBiology 2000, 2(1):comment2001.1–2001.6
The electronic version of this article is the complete one and can be
found online at /2000/2/1/comment/2001
? GenomeB (Print ISSN 1465-6906; Online ISSN 1465-6914)
Abstract
The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the
immune system, suggests that this type of genetic variation is functionally and evolutionarily far more
important than has been suspected, and provides a lead to new therapeutic strategies.
Considerable attention recently has focused on polymor-
phisms and their potential subtly to alter protein function in
ways that might prove biologically or clinically important.
But increasing numbers of polymorphisms are also being
identified in the regulatory regions of genes, and here I con-
sider the significance of these. Reflecting my perspective as
an immunologist, this article takes as its starting point the
posy of recently discovered polymorphisms associated with
autoimmunity, atopy and resistance to infection that are
shown in Table 1. I use the word ?posy? to indicate that, in
spite of my effort to make the survey comprehensive, it may
well be incomplete. To make sense of the distribution of
polymorphisms, I focus here on ?introvert? genes, which have
been defined as genes encoding proteins that handle self
molecules, as opposed to ?extrovert? genes, which encode
proteins that handle foreign molecules that enter the body
from outside [1,2]. In the former, non-coding variation pre-
dominates, as distinct from extrovert genes, in which the
reverse applies, at
您可能关注的文档
- Polymers An Interdisciplinary Open Access Journal 英文参考文献.doc
- Polymorphic variants in exon 8 at the 3' UTR of the HLA-G gene are associated with septic shock in critically ill patients 英文参考文献.doc
- Polymicrobial Nature of Chronic Diabetic Foot Ulcer Biofilm Infections Determined Using Bacterial Tag Encoded FLX Amplicon Pyrosequencing (bTEFAP) 英文参考文献.doc
- Polymers – A New Open Access Scientific Journal on Polymer Science 英文参考文献.doc
- Polymerase chain reaction detection of sepsis-inducing pathogens in blood using SepsiTest? 英文参考文献.doc
- Polymorphism Data Can Reveal the Origin of Species Abundance Statistics 英文参考文献.doc
- Polymorphic Variation of Genes in the Fibrinolytic System and the Risk of Ovarian Cancer 英文参考文献.doc
- Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors 英文参考文献.doc
- Polymer and Water Dynamics in Poly(vinyl alcohol)Poly(methacrylate) Networks. A Molecular Dynamics Simulation and Incoherent Neutron Scattering Investigation 英文参考文献.doc
- Polymerization in Liquid Crystal Medium Preparation of Polythiophene Derivatives Bearing a Bulky Pyrimidine Substituent 英文参考文献.doc
文档评论(0)