Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer 英文参考文献.docVIP
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Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer 英文参考文献
PolymorphismsinThioredoxinReductaseand
SelenoproteinKGenesandSeleniumStatusModulate
RiskofProstateCancer
CatherineMe′plan1,2,SabineRohrmann3,4,AstridSteinbrecher4,LutzSchomburg5,Euge`neJansen6,
JakobLinseisen4,7,JohnHesketh1,2
*
1InstituteforCellandMolecularBiosciences,NewcastleUniversity,Newcastle-upon-Tyne,UnitedKingdom, 2HumanNutritionResearchCentre,NewcastleUniversity,
Newcastle-upon-Tyne, United Kingdom, 3Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Zurich,
Switzerland,4DivisionofCancerEpidemiology,GermanCancerResearchCenter,Heidelberg,Germany,5InstituteforExperimentalEndocrinology,Charite′ -University
Medicine Berlin, Berlin, Germany, 6Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands,
7InstituteofEpidemiology,HelmholtzZentrumMu¨nchen,Neuherberg,Germany
Abstract
IncreaseddietaryintakeofSelenium(Se)hasbeensuggestedtolowerprostatecancermortality,butsupplementationtrials
haveproducedconflictingresults.Seisincorporatedinto25selenoproteins.Theaimofthisworkwastoassesswhetherrisk
ofprostatecancerisaffectedbygeneticvariantsingenescodingforselenoproteins,eitheraloneorincombinationwithSe
status. 248 cases and 492 controls from an EPIC-Heidelberg nested case-control study were subjected to two-stage
genotypingwithaninitialscreeningphaseinwhich384tagging-SNPscovering72Se-relatedgenesweredeterminedin94
casesand94controlsusingtheIlluminaGoldengatemethodology.Thisanalysiswasfollowedbyasecondphaseinwhich
genotypingforcandidateSNPsidentifiedinthefirstphasewascarriedoutinthefullstudyusingSequenom.Riskofhigh-
gradeoradvancedstageprostatecancerwasmodifiedbyinteractionsbetweenserummarkersofSestatusandgenotypes
for rs9880056 in SELK, rs9605030 and rs9605031 in TXNRD2,and rs7310505 in TXNRD1. No significant effects of SNPs on
prostatecancerriskwereobservedwhengradeorSestatuswasnottakenintoaccount.Inconclusion,theriskofhigh
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