Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Troms？ Study 英文参考文献.docVIP

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Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Troms？ Study 英文参考文献.doc

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Polymorphisms Related to the Serum 25-Hydroxyvitamin D Level and Risk of Myocardial Infarction, Diabetes, Cancer and Mortality. The Troms？ Study 英文参考文献

PolymorphismsRelatedtotheSerum25-Hydroxyvitamin DLevelandRiskofMyocardialInfarction,Diabetes, CancerandMortality.TheTroms?Study RolfJorde1*,HenrikSchirmer2,TomWilsgaard3,RagnarMartinJoakimsen1,EllisivB?gebergMathiesen4, IngerNj?lstad3,Maja-LisaL?chen3,YngveFigenschau5,JensPetterBerg6,JohanSvartberg1, GuriGrimnes1 1Troms?EndocrineResearchGroup,DepartmentofClinicalMedicine,UniversityofTroms?,Troms?,NorwayandDivisionofInternalMedicine,UniversityHospitalof NorthNorway,Troms?,Norway,2DepartmentofClinicalMedicine,UniversityofTroms?,Troms?,Norway,3DepartmentofCommunityMedicine,UniversityofTroms?, Troms?, Norway,4Brain and Circulation Research Group, Department of Clinical Medicine, University of Troms?, Troms?, Norway and Department ofNeurologyand Neurophysiology, University Hospital of North Norway, Troms?, Norway, 5Department of Medical Biology, Faculty of Health Sciences, University of Troms?, Troms?, Norway and Department of Laboratory Medicine, University Hospital of North Norway, Troms?, Norway, 6Department of Medical Biochemistry, Institute of Clinical Medicine,UniversityofOsloandOsloUniversityHospital,Oslo,Norway Abstract Objective: Low serum 25(OH)D levels are associated with cardiovascular risk factors, and also predict future myocardial infarction(MI),type2diabetes(T2DM),cancerandall-causemortality.Recentlyseveralsinglenucleotidepolymorphisms (SNPs)associatedwithserum25-hydroxyvitaminD(25(OH)D)levelhavebeenidentified.Iftheserelationsarecausalone wouldexpectasimilarassociationbetweentheseSNPsandhealth. Methods:DNAwaspreparedfromsubjectswhoparticipatedinthefourthsurveyoftheTroms?Studyin1994–1995and who were registered with the endpoints MI, T2DM, cancer or death as well as a randomly selected control group. The endpointregisterswerecompleteupto2007–2010.Genotypingwasperformedfor17SNPsrelatedtotheserum25(OH)D level. Results:Atotalof9528subjectswereselectedforgeneticanalyseswhichweresuccessfullyperformedforatleastoneSNP in9471subjects.Amongthese,2025wereregistered