Polymorphisms on 8q24 Are Associated with Lung Cancer Risk and Survival in Han Chinese 英文参考文献.docVIP
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Polymorphisms on 8q24 Are Associated with Lung Cancer Risk and Survival in Han Chinese 英文参考文献
Polymorphismson8q24AreAssociatedwithLung
CancerRiskandSurvivalinHanChinese
XuelinZhang1.,QunChen2.,ChunyaHe3.,WeihuaMao1,LingZhang4,XiaowenXu1,JunfeiZhu5,
BaofuChen1,6
*
1DepartmentofThoracicSurgery,TaizhouCentralHospital,Taizhou,Zhejiang,China,2DepartmentofOncology,FuzhouPulmonaryHospital,FujianMedicalUniversity,
Fuzhou, Fujian, China, 3Department of Surgical Oncology, Taizhou Central Hospital, Taizhou, Zhejiang, China, 4Department of Gynaecology and Obstetrics, Taizhou
CentralHospital,Taizhou,Zhejiang,China,5DepartmentofRespiratoryMedicine,TaizhouCentralHospital,Taizhou,Zhejiang,China,6DepartmentofThoracicSurgery,
TaizhouHospital,Taizhou,Zhejiang,China
Abstract
Chromosome8q24iscommonlyamplifiedinmanytypesofcancer,particularlylungcancer.Polymorphismsinthisregion
areassociatedwithriskofdifferentcancers.Toinvestigatetherelationshipbetweenthreesinglenucleotidepolymorphisms
(SNPs)(rs1447295,rndrs6983267)on8q24andlungcancerrisk,weconductedanassociationstudyintwoHan
Chinesepopulations:onepopulationwasfromZhejiangProvince(576casepatientsand576controlsubjects),whereasthe
other was from Fujian Province (576 case patients and 576 control subjects). We found that rs6983267 was significantly
associatedwithanincreasedriskoflungcancerinbothpopulations.ComparedwiththeTTgenotype,theGGgenotype
was associated with a significant 1.555-fold increased risk of lung cancer [95% confidence interval (CI) 1.218–1.986,
P=4.061024]. This effect was more pronounced in never-smokers [odds ratio (OR)=2.366, 95% CI 1.605–3.488,
P=1.461025].Analysesstratifiedbyhistologyrevealedthatrs6983267GGgenotypewasmostassociatedwithpatientswith
otherhistologicaltypes(OR=3.012,95%CI1.675–5.417,P=2.361024).TheAAgenotypeofrs1447295wasassociatedwith
increased risk for adenocarcinoma compared with the CC genotype (OR=2.260, 95% CI 1.174–4.353, P =0.015).
Furthermore,theGGgenotypeofrs6983267wasassociatedwithworsesurvivalintheZhejiangpopulation(hazardratio
(HR)=1.646,95%CI1.099–2.464,P=0.016).Noassoc
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