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Porous Silicon Based Resonant Mirrors for Biochemical Sensing 英文参考文献
Sensors 2008, 8, 6549-6556; DOI: 10.3390/s8106549
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Article
Porous Silicon Based Resonant Mirrors for Biochemical Sensing
Edoardo De Tommasi 1,*, Luca De Stefano 1, Ilaria Rea 1, 2, Valentina Di Sarno
1, 2
,
Lucia Rotiroti 1,3, Paolo Arcari 4, Annalisa Lamberti 4, Carmen Sanges 4 and Ivo Rendina 1
1 Institute for Microelectronics and Microsystems – Unit of Naples – National Council of Research,
Via P. Castellino 111, 80131 Napoli, Italy.
2 Department of Physical Sciences, University of Naples “Federico II”, Via Cinthia, 80126 Naples,
Italy
3 Department of Organic Chemistry and Biochemistry, University of Naples “Federico II”, Via
Cinthia, 80128 Napoli, Italy
4 Department of Biochemistry and Medical Biotechnologies, University of Naples “Federico II”, Via
S. Pansini 5, 80131 Napoli, Italy.
* Author to whom correspondence should be addressed: edetommasi@r.it
Received: 6 June 2008; in revised form: 6 October 2008 / Accepted: 21 October 2008 / Published: 23
October 2008
Abstract: We report on our preliminary results in the realization and characterization of a
porous silicon (PSi) resonant mirror (RM) for optical biosensing. We have numerically and
experimentally studied the coupling between the electromagnetic field, totally reflected at
the base of a high refractive index prism, and the optical modes of a PSi waveguide. This
configuration is very sensitive to changes in the refractive index and/or in thickness of the
sensor surface. Due to the high specific area of the PSi waveguide, very low DNA
concentrations can be detected confirming that the RM could be a very sensitive and label-
free optical biosensor.
Keywords: DNA Optical Biosensors, Porous Silicon, Resonant Mirrors.
1. Introduction
Optical label-free biosensors are ideal candidates for high throughput screening in the prevention of
bio-threat agents or social illnesses: all the different configurations
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