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Post-transplant diabetes mellitus 英文参考文献
Diabetology Metabolic Syndrome
BioMedCentral
Review
Open Access
Post-transplant diabetes mellitus
Marília B Gomes*1 and Roberta A Cobas2
Address: 1Diabetes and Metabology Unit from Pedro Ernesto University Hospital, Medical Science School, State University of Rio de Janeiro (UERJ
and 2Program in Clinical and Experimental Pathophysiology (PGCLINEX) Diabetes and Metabology Unit, Pedro Ernesto University Hospital,
State University of Rio de Janeiro (UERJ
Email: Marília B Gomes* - mariliabgomes@.br; Roberta A Cobas - robertacobas@.br
* Corresponding author
Published: 5 October 2009
Received: 26 March 2009
Accepted: 5 October 2009
Diabetology Metabolic Syndrome 2009, 1:14
doi:10.1186/1758-5996-1-14
This article is available from: /content/1/1/14
? 2009 Gomes and Cobas; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In recent decades, Diabetes Mellitus has become a severe and growing global public healthcare
problem due to the increase of its prevalence, morbidity and mortality. Post-transplant diabetes
mellitus (PTDM) is a complication which takes place after a solid organ transplant, and its incidence
is widely variable, ranging from 2 to 53%. Some factors increase the risk of PTDM, such as age,
ethnicity, cadaver-donor kidney presence of the hepatitis C virus and cytomegalovirus, overweight
and obesity and the Immunosuppression scheme established in the immediate post-transplant
period. High doses of tacrolimus and corticosteroid represent the highest risk for developing
PTDM.
Considering that the development of PTDM is associated with a higher risk of complications, such
as infections and cardiovascular disease - thus representing a higher life threatening risk and a
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