Power for mapping quantitative trait loci in crosses between outbred lines in pigs 英文参考文献.docVIP

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Power for mapping quantitative trait loci in crosses between outbred lines in pigs 英文参考文献.doc

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Power for mapping quantitative trait loci in crosses between outbred lines in pigs 英文参考文献

Power for mapping trait loci in crosses outbred lines in pigs Department of Animal Science, Agricultural University of Norway, Box 5025, N-1432 As, Norway (Received 28 May 1998; accepted 12 May 1999) Abstract - Power for mapping quantitative trait loci using crosses between segregat- ing populations was studied in pigs. Crossing generates gametic disequilibrium increases heterozygosity. The condition for a heterozygosity among be 1/2 in one line and higher than 1/2 in the other line. greater than in either line at crossing is that allele frequency should be lower than Maximum expected power and expected risk were used to compare hierarchical backcross (each boar mated to several sows; contrast within boars), hierarchical intercross (each boar mated to several sows; contrast within both boars and sows) and traditional intercross (each boar mated to one sow; contrast within both boars and sows). The use of hierarchical designs (back- cross and intercross) increased power for traits with low or intermediate heritabilities. For small QTL effects and low heritabilities the hierarchical backcross design gave the highest expected power but also the highest risk. There is not a general design which allocates resources in an optimum fashion across situations (heritabilities, QTL A requires between four (maximum expected power) and eight boars (minimum risk) to detect a QTL of 0.5 phenotypic standard deviations. Selection of extreme individuals in parental lines increased power up to 21 %. Commercial crosses are proposed as an alternative to experiments for QTL mapping. @ Inra/Elsevier, Paris gene mapping / quantitative trait locus / statistical power / hierarchical design / pig entre lignées non consanguines chez le porc. On a étudié chez le porc de détection des loci à effets quantitatifs à partir de croisements entre populations en IF ségrégation. Le niveau d’hétérozygotie chez les individus est supérieur à celui de * E-mail: luis.gomez.raya!akvaforsk.nl