Prediction by Promoter Logic in Bacterial Quorum Sensing 英文参考文献.docVIP

下载本文档

22
0
约8.14万字
约 14页
2017-05-12 发布于上海
举报
版权申诉

Prediction by Promoter Logic in Bacterial Quorum Sensing 英文参考文献.doc

1、本文档共14页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Prediction by Promoter Logic in Bacterial Quorum Sensing 英文参考文献

PredictionbyPromoterLogicinBacterialQuorum Sensing NavneetRai1,2,RajatAnand1,KrishnaRamkumar3,VarunSreenivasan4,SugatDabholkar1,K.V. Venkatesh2,MukundThattai1* 1NationalCentreforBiologicalSciences,TataInstituteofFundamentalResearch,UAS/GKVKCampus,Bangalore,India,2DepartmentofBioSciencesandBioengineering, IndianInstituteofTechnologyBombay,Powai,Mumbai,India,3DepartmentofChemistry,IndianInstituteofTechnologyBombay,Powai,Mumbai,India,4Departmentof BiologicalSciences,St.Xavier’sCollege,Mumbai,India Abstract Quorum-sensing systems mediate chemical communication between bacterial cells, coordinating cell-density-dependent processes like biofilm formation and virulence-factor expression. In the proteobacterial LuxI/LuxR quorum sensing paradigm, a signaling molecule generated by an enzyme (LuxI) diffuses between cells and allosterically stimulates a transcriptionalregulator(LuxR)toactivateitscognatepromoter(pR).ByexpressingeitherLuxIorLuxRinpositivefeedback frompR,theseversatilesystemscangeneratesmooth(monostable)orabrupt(bistable)density-dependentresponsesto suittheecologicalcontext.HerewecombinetheoryandexperimenttodemonstratethatthepromoterlogicofpR–its measuredactivityasafunctionofLuxIandLuxRlevels–containsallthebiochemicalinformationrequiredtoquantitatively predict the responses of such feedback loops. The interplay of promoter logic with feedback topology underlies the versatilityoftheLuxI/LuxRparadigm:LuxRandLuxIpositive-feedbacksystemsshowdramaticallydifferentresponses,while a dual positive/negative-feedback system displays synchronized oscillations. These results highlight the dual utility of promoterlogic:toprobemicroscopicparametersandpredictmacroscopicphenotype. Citation:RaiN,AnandR,RamkumarK,SreenivasanV,DabholkarS,etal.(2012)PredictionbyPromoterLogicinBacterialQuorumSensing.PLoSComputBiol8(1): e1002361.doi:10.1371/journal.pcbi.1002361 Editor:NicolasBuchler,DukeInstituteforGenomeSciencesPolicy,UnitedStatesofAmerica ReceivedJuly4,2011;AcceptedDecember8,2011;Pu