Prediction of Altered 3′- UTR miRNA-Binding Sites from RNA-Seq Data The Swine Leukocyte Antigen Complex (SLA) as a Model Region 英文参考文献.docVIP

下载本文档

2
0
约5.54万字
约 11页
2017-05-12 发布于上海
举报
版权申诉

Prediction of Altered 3′- UTR miRNA-Binding Sites from RNA-Seq Data The Swine Leukocyte Antigen Complex (SLA) as a Model Region 英文参考文献.doc

1、本文档共11页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Prediction of Altered 3′- UTR miRNA-Binding Sites from RNA-Seq Data The Swine Leukocyte Antigen Complex (SLA) as a Model Region 英文参考文献

PredictionofAltered39-UTRmiRNA-BindingSitesfrom RNA-SeqData:TheSwineLeukocyteAntigenComplex (SLA)asaModelRegion Marie-LaureEndaleAhanda1,2,3,EricR.Fritz4,JordiEstelle′1,2,3,Zhi-LiangHu4,OleMadsen5, MartienA.M.Groenen5,DarioBeraldi6¤,RonanKapetanovic6,DavidA.Hume6,RobertR.R.Rowland7, JoanK.Lunney8,ClaireRogel-Gaillard1,2,3,JamesM.Reecy4,ElisabettaGiuffra1,2,3* 1INRA,UMR1313deGe′ne′tiqueAnimaleet BiologieInte′grative,DomainedeVilvert,Jouy-en-Josas,France, 2CEA,DSV,IRCM,SREIT, LaboratoiredeRadiobiologieet EtudeduGe′nome, DomainedeVilvert,Jouy-en-Josas,France,3AgroParisTech,LaboratoiredeGe′ne′tique AnimaleetBiologieInte′grative,DomainedeVilvert,Jouy-en- Josas, France, 4Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, United States of America, 5Animal BreedingandGenomicsCentre,WageningenUniversity,Wageningen,TheNetherlands,6TheRoslinInstituteandRoyal(Dick)SchoolofVeterinaryStudies,Universityof Edinburgh,Midlothian,UnitedKingdom,7DepartmentofDiagnosticMedicineandPathobiology,KansasStateUniversity,Manhattan,Kansas,UnitedStatesofAmerica, 8AnimalParasiticDiseasesLaboratory,BeltsvilleAgriculturalResearchCenter,AgriculturalResearchService,UnitedStatesDepartmentofAgriculture,Beltsville,Maryland, UnitedStatesofAmerica Abstract TheSLA(swineleukocyteantigen,MHC:SLA)genesarethemostimportantdeterminantsofimmune,infectiousdiseaseand vaccine response in pigs; several genetic associations with immunity and swine production traits have been reported. However,mostofthecurrentknowledgeonSLAislimitedtogenecodingregions.MicroRNAs(miRNAs)aresmallmolecules that post-transcriptionally regulate the expression of a large number of protein-coding genes in metazoans, and are suggested to play important roles in fine-tuning immune mechanisms and disease responses. Polymorphisms in either miRNAs or their gene targets may have a significant impact on gene expression by abolishing, weakening or creating miRNAtargetsites,possibly