Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks 英文参考文献.docVIP

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Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks 英文参考文献.doc

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Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks 英文参考文献

PredictionofC.elegansLongevityGenesbyHumanand WormLongevityNetworks RobiTacutu1.,DavidE.Shore2,3.,ArieBudovsky1.,Joa?oPedrodeMagalha?es4,GaryRuvkun2,3, VadimE.Fraifeld1*,SeanP.Curran5,6,7* 1TheShragaSegalDepartmentofMicrobiology,ImmunologyandGenetics,CenterforMultidisciplinaryResearchonAging,Ben-GurionUniversityoftheNegev,Beer- Sheva,Israel,2DepartmentofMolecularBiology,MassachusettsGeneralHospital,Boston,Massachusetts,UnitedStatesofAmerica,3DepartmentofGenetics,Harvard Medical School, Boston, Massachusetts, United States of America, 4Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool,UnitedKingdom,5DivisionofBiogerontology,DavisSchoolofGerontology,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStatesofAmerica, 6DepartmentofMolecularandComputationalBiology,DornsifeCollegeofLetters,Arts,andSciences,UniversityofSouthernCalifornia,LosAngeles,California,United StatesofAmerica,7DepartmentofBiochemistryandMolecularBiology,KeckSchoolofMedicine,UniversityofSouthernCalifornia,LosAngeles,California,UnitedStates ofAmerica Abstract Intricateandinterconnectedpathwaysmodulatelongevity,butscreenstoidentifythecomponentsofthesepathwayshave notbeensaturating.Becausebiologicalprocessesareoftenexecutedbyproteincomplexesandfine-tunedbyregulatory factors, the first-order protein-protein interactors of known longevity genes are likely to participate in the regulation of longevity.Data-richmapsofproteininteractionshavebeenestablishedformanycardinalorganismssuchasyeast,worms, andhumans.Weproposethattheseinteractionmapscouldbeminedfortheidentificationofnewputativeregulatorsof longevity.Forthispurpose,wehaveconstructedlongevitynetworksinbothhumansandworms.Wereasonedthatthe essential first-order interactors of known longevity-associated genes in these networks are morelikely tohavelongevity phenotypesthanrandomlychosengenes.WehaveusedC.eleganstodeterminewhetherpost-developmentalinactivation of these essential genes modulates