Predictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleus 英文参考文献.docVIP
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Predictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleus 英文参考文献
PredictiveFeedbackCanAccountforBiphasicResponses
intheLateralGeniculateNucleus
JannekeF.M.Jehee1,2*,DanaH.Ballard1,3
1CenterforVisualScienceandDepartmentofComputerScience,UniversityofRochester,Rochester,NewYork,UnitedStatesofAmerica,2DepartmentofPsychology,
VanderbiltUniversity,Nashville,Tennessee,UnitedStatesofAmerica,3DepartmentofComputerScience,UniversityofTexasatAustin,Austin,Texas,UnitedStatesof
America
Abstract
Biphasicneuralresponseproperties,wheretheoptimalstimulusfordrivinganeuralresponsechangesfromonestimulus
patterntotheoppositestimuluspatternovershortperiodsoftime,havebeendescribedinseveralvisualareas,including
lateralgeniculatenucleus(LGN),primaryvisualcortex(V1),andmiddletemporalarea(MT).Wedescribeahierarchicalmodel
ofpredictivecodingandsimulationsthatcapturethesetemporalvariationsinneuronalresponseproperties.Wefocuson
the LGN-V1 circuit and find that after training on natural images the model exhibits the brain’s LGN-V1 connectivity
structure,inwhichthestructureofV1receptivefieldsislinkedtothespatialalignmentandpropertiesofcenter-surround
cellsintheLGN.Inaddition,thespatio-temporalresponseprofileofLGNmodelneuronsisbiphasicinstructure,resembling
the biphasic response structure of neurons in cat LGN. Moreover, the model displays a specific pattern of influence of
feedback,whereLGNreceptivefieldsthatarealignedoverasimplecellreceptivefieldzoneofthesamepolaritydecrease
theirresponseswhileneuronsofoppositepolarityincreasetheirresponseswithfeedback.Thisphase-reversedpatternof
influencewasrecentlyobservedinneurophysiology.Theseresultscorroboratetheideathatpredictivefeedbackisageneral
codingstrategyinthebrain.
Citation: Jehee JFM, Ballard DH (2009) Predictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleus. PLoS Comput Biol 5(5):
e1000373.doi:10.1371/journal.pcbi.1000373
Editor:KarlJ.Friston,UniversityCollegeLondon,UnitedKingdom
ReceivedNovember14,2008;AcceptedMarch24,2009;PublishedMay1,2009
Copyright: ? 2009 Jehee et al. This i
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