Prediction of genetic gain from quadratic optimisation with constrained rates of inbreeding 英文参考文献.docVIP
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Prediction of genetic gain from quadratic optimisation with constrained rates of inbreeding 英文参考文献
Genet.Sel.Evol.38(2006)127–146
c INRA,EDPSciences,2006
DOI:10.1051/gse:2005032
127
Originalarticle
Predictionofgeneticgainfromquadratic
optimisationwithconstrainedrates
ofinbreeding
BeatrizVillanuevaa?,SantiagoAvendano? a,
JohnA.Woolliams
b
a
ScottishAgriculturalCollege,WestMainsRoad,Edinburgh,EH93JG,Scotland,UK
b
RoslinInstitute(Edinburgh),Roslin,Midlothian,EH259PS,UK
(Received11April2005;accepted7October2005)
Abstract–Thereareselectionmethodsavailablethatallowtheoptimisationofgeneticcontri-
butionsofselectioncandidatesformaximisingtherateofgeneticgainwhilerestrictingtherate
ofinbreeding.Thesemethodsimplyselectiononquadraticindicesastheselectionmeritofa
particularindividualisaquadraticfunctionofitsestimatedbreedingvalue.Thisstudyprovides
deterministicpredictionsofgeneticgainfromselectiononquadraticindicesforagivensetof
resources(thenumberofcandidates),heritability,andtargetrateofinbreeding.Therateofgain
wasobtainedasafunctionoftheaccuracyoftheMendeliansamplingtermatthetimeofcon-
vergenceoflong-termcontributionsofselectedcandidatesandthetheoreticalidealrateofgain
foragivenrateofinbreedingafteranexactallocationoflong-termcontributionstoMendelian
samplingterms.Theexpectedbene?tsfromquadraticindicesovertraditionallinearindices(i.e.
truncationselection),bothusingBLUPbreedingvalues,werequanti?ed.Theresultsclearlyin-
dicatehighergainsfromquadraticoptimisationthanfromtruncationselection.Withconstant
rateofinbreedingandnumberofcandidates,thebene?tsweregenerallylargestforintermedi-
ateheritabilitiesbutevidentovertheentirerange.Theadvantageofquadraticindiceswasnot
highlysensitivetotherateofinbreedingfortheconstraintsconsidered.
predictionofgeneticgain/quadraticindices/controlofinbreeding/geneticcontributions
1. INTRODUCTION
Quadraticoptimisation[7,8,10,11]providesasolutiontotheproblemofop-
timisingselectiondecisionsinbreedingschemesformaximisinggeneticgain
(ΔG)withconstrained ratesofinbreeding (ΔF).Theselectionmeritofindi-
vidualcandidatesisaquadraticfunctionoftheirest
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