Predictive Features of Persistent Activity Emergence in Regular Spiking and Intrinsic Bursting Model Neurons 英文参考文献.docVIP

PredictiveFeaturesofPersistentActivityEmergencein RegularSpikingandIntrinsicBurstingModelNeurons KyriakiSidiropoulou,PanayiotaPoirazi* InstituteofMolecularBiologyandBiotechnology(IMBB),FoundationforResearchandTechnology-Hellas(FORTH),Heraklion,Crete,Greece Abstract Properfunctioningofworkingmemoryinvolvestheexpressionofstimulus-selectivepersistentactivityinpyramidalneurons oftheprefrontalcortex(PFC),whichreferstoneuralactivitythatpersistsforsecondsbeyondtheendofthestimulus.The mechanismswhichPFCpyramidalneuronsusetodiscriminatebetweenpreferredvs.neutralinputsatthecellularlevelare largelyunknown.Moreover,thepresenceofpyramidalcellsubtypeswithdifferentfiringpatterns,suchasregularspiking andintrinsicbursting,raisesthequestionastowhattheirdistinctrolemightbeinpersistentfiringinthePFC.Here,weuse acompartmentalmodelingapproachtosearchfordiscriminatoryfeaturesinthepropertiesofincomingstimulitoaPFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementingaregularspiking(RS)andanintrinsicbursting(IB)modelneuron.Weidentifysynapticlocationwithinthe basal dendrites as a feature of stimulus selectivity. Specifically, persistent activity-inducing stimuli consist of activated synapsesthatarelocatedmoredistallyfromthesomacomparedtonon-inducingstimuli,inbothmodelcells.Inaddition, the action potential (AP) latency and the first few inter-spike-intervals of the neuronal response can be used to reliably detect inducing vs. non-inducing inputs, suggesting a potential mechanism by which downstream neurons can rapidly decodetheupcomingemergenceofpersistentactivity.Whilethetwomodelneuronsdidnotdifferinthecodingfeatures of persistent activity emergence, the properties of persistent activity, such as the firing pattern and the duration of temporally-restrictedpersistentactivityweredistinct.Collectiv