Predictors and Prevalence of Latent Tuberculosis Infection in Patients Receiving Long-Term Hemodialysis and Peritoneal Dialysis 英文参考文献.docVIP

Predictors and Prevalence of Latent Tuberculosis Infection in Patients Receiving Long-Term Hemodialysis and Peritoneal Dialysis 英文参考文献.doc

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Predictors and Prevalence of Latent Tuberculosis Infection in Patients Receiving Long-Term Hemodialysis and Peritoneal Dialysis 英文参考文献

PredictorsandPrevalenceofLatentTuberculosis InfectioninPatientsReceivingLong-TermHemodialysis andPeritonealDialysis Chin-ChungShu1,2,Vin-CentWu2,3,Feng-JungYang4,Sung-ChingPan3,Tai-ShuanLai5 ,Jann- YuanWang2,3*,Jann-TayWang2,3,Li-NaLee6 1DepartmentofTraumatology,NationalTaiwanUniversityHospital,TaipeiCity,Taiwan,2CollegeofInternalMedicine,NationalTaiwanUniversity,TaipeiCity,Taiwan, 3DepartmentofInternalMedicine,NationalTaiwanUniversityHospital,TaipeiCity,Taiwan,4DepartmentofInternalMedicine,NationalTaiwanUniversityHospital,Yun- Lin Branch, Yun-Lin County, Taiwan, 5Department of Internal Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei City, Taiwan, 6Department of LaboratoryMedicine,NationalTaiwanUniversityHospital,TaipeiCity,Taiwan Abstract Background: Tuberculosis is a common infectious disease in long-term dialysis patients. The prevalence of latent tuberculosisinfection(LTBI)inthispopulationisunclear,particularlyinthosereceivingperitonealdialysis(PD).Thisstudy investigatedtheprevalenceofLTBIinpatientsreceivingeitherhemodialysis(HD)orPDtodeterminepredictorsofLTBIand indeterminateresultsofinterferon-gammareleaseassay. Methods:Patientsreceivinglong-term($3months)HDorPDfromMarch2011toFebruary2012intwomedicalcenters wereprospectivelyenrolled.QuantiFERON-Goldintube(QFT)testwasusedtodeterminethestatusofLTBIafterexcluding activetuberculosis.TheLTBIprevalencewasdeterminedinpatientsreceivingdifferentdialysismodestoobtainpredictors ofLTBIandQFT-indeterminateresults. Results: Of 427patients enrolled(124PD and303HD), 91(21.3%)wereQFT-positive, 316(74.0%)QFT-negative, and20 (4.7%)QFT-indeterminate.TheprevalenceofLTBIwassimilarinthePDandHDgroups.IndependentpredictorsofLTBIwere oldage(OR:1.034[1.013–1.056]peryearincrement),TBhistory(OR:6.467[1.985–21.066]),andcurrentsmoker(OR:2.675 [1.061–6.747]).FactorsassociatedwithindeterminateQFTresultswereHD(OR:10.535[1.336–83.093]),dialysisduration(OR: 1.113 [1.015–1.221] per year increment), anemia (OR: 8.760 [1.0

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