Predictors and Prevalence of Latent Tuberculosis Infection in Patients Receiving Long-Term Hemodialysis and Peritoneal Dialysis 英文参考文献.docVIP
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Predictors and Prevalence of Latent Tuberculosis Infection in Patients Receiving Long-Term Hemodialysis and Peritoneal Dialysis 英文参考文献
PredictorsandPrevalenceofLatentTuberculosis
InfectioninPatientsReceivingLong-TermHemodialysis
andPeritonealDialysis
Chin-ChungShu1,2,Vin-CentWu2,3,Feng-JungYang4,Sung-ChingPan3,Tai-ShuanLai5 ,Jann-
YuanWang2,3*,Jann-TayWang2,3,Li-NaLee6
1DepartmentofTraumatology,NationalTaiwanUniversityHospital,TaipeiCity,Taiwan,2CollegeofInternalMedicine,NationalTaiwanUniversity,TaipeiCity,Taiwan,
3DepartmentofInternalMedicine,NationalTaiwanUniversityHospital,TaipeiCity,Taiwan,4DepartmentofInternalMedicine,NationalTaiwanUniversityHospital,Yun-
Lin Branch, Yun-Lin County, Taiwan, 5Department of Internal Medicine, National Taiwan University Hospital, Bei-Hu Branch, Taipei City, Taiwan, 6Department of
LaboratoryMedicine,NationalTaiwanUniversityHospital,TaipeiCity,Taiwan
Abstract
Background: Tuberculosis is a common infectious disease in long-term dialysis patients. The prevalence of latent
tuberculosisinfection(LTBI)inthispopulationisunclear,particularlyinthosereceivingperitonealdialysis(PD).Thisstudy
investigatedtheprevalenceofLTBIinpatientsreceivingeitherhemodialysis(HD)orPDtodeterminepredictorsofLTBIand
indeterminateresultsofinterferon-gammareleaseassay.
Methods:Patientsreceivinglong-term($3months)HDorPDfromMarch2011toFebruary2012intwomedicalcenters
wereprospectivelyenrolled.QuantiFERON-Goldintube(QFT)testwasusedtodeterminethestatusofLTBIafterexcluding
activetuberculosis.TheLTBIprevalencewasdeterminedinpatientsreceivingdifferentdialysismodestoobtainpredictors
ofLTBIandQFT-indeterminateresults.
Results: Of 427patients enrolled(124PD and303HD), 91(21.3%)wereQFT-positive, 316(74.0%)QFT-negative, and20
(4.7%)QFT-indeterminate.TheprevalenceofLTBIwassimilarinthePDandHDgroups.IndependentpredictorsofLTBIwere
oldage(OR:1.034[1.013–1.056]peryearincrement),TBhistory(OR:6.467[1.985–21.066]),andcurrentsmoker(OR:2.675
[1.061–6.747]).FactorsassociatedwithindeterminateQFTresultswereHD(OR:10.535[1.336–83.093]),dialysisduration(OR:
1.113 [1.015–1.221] per year increment), anemia (OR: 8.760 [1.0
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