Preliminary Phytochemical Screening and In Vitro Anti-Helicobacter pylori Activity of Extracts of the Stem Bark of Bridelia micrantha (Hochst., Baill., Euphorbiaceae) 英文参考文献.docVIP

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Preliminary Phytochemical Screening and In Vitro Anti-Helicobacter pylori Activity of Extracts of the Stem Bark of Bridelia micrantha (Hochst., Baill., Euphorbiaceae) 英文参考文献.doc

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Preliminary Phytochemical Screening and In Vitro Anti-Helicobacter pylori Activity of Extracts of the Stem Bark of Bridelia micrantha (Hochst., Baill., Euphorbiaceae) 英文参考文献

Molecules 2011, 16, 6193-6205; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Preliminary Phytochemical Screening and In Vitro Anti-Helicobacter pylori Activity of Extracts of the Stem Bark of Bridelia micrantha (Hochst., Baill., Euphorbiaceae) Benjamin I. Okeleye 1, Pascal O. Bessong 2 and Roland N. Ndip 1,3,* 1 Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Fort Hare, P/Bag X1314, Alice 5700, South Africa; E-Mail: 200803960@ufh.ac.za (B.I.O.) 2 AIDS Virus Research Laboratory, Department of Microbiology, University of Venda, Thohoyandou 0950, South Africa; E-Mail: pascal.bessong@univen.ac.za (P.O.B.) 3 Department of Biochemistry and Microbiology, Faculty of Science, University of Buea, Box 63, Buea, Cameroon * Author to whom correspondence should be addressed; E-Mail: ndip3@; Tel: +27-782696191; Fax: +27-866224759. Received: 17 June 2011; in revised form: 15 July 2011 / Accepted: 21 July 2011 / Published: 25 July 2011 Abstract: Helicobacter pylori is a major risk factor for gastritis, ulcers and gastric cancer. This study was aimed to determine the antimicrobial activity of the stem bark of Bridelia. micrantha on H. pylori isolated in South Africa. Extracts and clarithromycin were tested against 31 clinical strains, including a standard strain (NCTC 11638) of H. pylori, by measuring the diameters of the corresponding inhibition zones, followed by determination of the Minimum Inhibitory Concentration (MIC) (using metronidazole, and amoxicillin as control antibiotics) and the rate of kill. Preliminary phytochemical screening was also done. Inhibition zone diameters which ranged from 0–23 mm were observed for all five of the extracts and 0–35 mm for clarithromycin. Marked susceptibility of strains (100%) was noted for the acetone extract (P 0.05), followed b