Predictors of outcome in myxoedema coma a study from a tertiary care centre 英文参考文献.docVIP

Available online /content/12/1/R1 Research Open Access Vol 12 No 1 Predictors of outcome in myxoedema coma: a study from a tertiary care centre Pinaki Dutta1, Anil Bhansali1, Shriq Rashid Masoodi1, Sanjay Bhadada1, Navneet Sharma2 and Rajesh Rajput1 1Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India 2Department of Critical Care Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India Corresponding author: Anil Bhansali, anilbhansali_endocrine@ Received: 17 Aug 2007 Revisions requested: 10 Sep 2007 Revisions received: 18 Oct 2007 Accepted: 3 Jan 2008 Published: 3 Jan 2008 Critical Care 2008, 12:R1 (doi:10.1186/cc6211) This article is online at: /content/12/1/R1 ? 2008 Dutta et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background With the easy availability of thyroid hormone assays, thyroid disorders are now recognised even in a subclinical state. However, patients are still seen with advanced the disease, particularly in developing countries. This observational study analysed the predictors of outcome in patients with myxoedema coma and tested the validity of different modules to define morbidity and mortality in these patients. presented early to the hospital and had more severe manifestations than de novo subjects. Nineteen (82%) had thyroprivic (primary) and 4 (17%) had trophoprivic (secondary) hypothyroidism. Fifteen (65%) patients presented in the winter and in 17 (74%) sepsis was the major accompanying comorbidity. Twelve (52%) had a history of diuretic use, thereby delaying the initial diagnosis. Patients who received oral